BACKGROUND Clinical outcomes of patients undergoing a cardiac implantable electronic device (CIED) implantation following a recent non-device related infection are unknown. AIM To evaluate the clinical outcomes of patients with recent infection before CIED implantation. METHODS Consecutive patients (N = 1237) were classified as patients with recent infection (N = 72) and without recent infection (N = 1165). A recent infection was established by reviewing medical records, including symptoms and clinical manifestations, diagnosis of systemic inflammatory response syndrome, and quick Sequential Organ Failure Assessment (qSOFA) score. Multiple stepwise logistic regression analysis was used to identify independent predictors of in-hospital all-cause mortality. FINDINGS During nearly three years of follow-up, 17 patients had CIED infection (1.4%), and the incidence of CIED infection did not significantly differ between patients with and without recent infection according to symptoms and clinical manifestations (2.8% vs 1.3%, respectively; not significant). However, patients with recent infection had a significantly higher in-hospital mortality rate compared to those without recent infection (22.2% vs 0.9%, respectively; P < 0.05). In multivariate analysis, predictors of in-hospital mortality were recent infection before CIED implantation (odds ratio: 20.3; 95% confidence interval: 8.4-49.3; P < 0.001) and end-stage renal disease (4.3; 1.4-12.8; P = 0.009). CONCLUSION A CIED implantation is feasible in patients with recent infection if the patient is afebrile and has received an adequate duration of antibiotic therapy. Participants in shared decision-making before implant should be advised that recent infection increases in-hospital mortality risk, especially in patients with a qSOFA score of ≥2.

中文翻译：

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在最近发生的与设备无关的感染之后，接受心脏可植入电子设备植入的患者的临床结局。

背景技术在最近与非设备相关的感染之后进行心脏可植入电子设备（CIED）植入的患者的临床结果尚不清楚。目的评估CIED植入前近期感染患者的临床结局。方法连续性患者（N = 1237）被分类为近期感染（N = 72）和没有近期感染（N = 1165）。通过查看病历，包括症状和临床表现，系统性炎症反应综合征的诊断以及快速的顺序器官衰竭评估（qSOFA）评分，确定了近期感染。采用多元逐步逻辑回归分析来确定院内全因死亡率的独立预测因子。结果在近三年的随访中，有17例患者发生了CIED感染（占1.4％），根据症状和临床表现，有无近期感染的患者之间CIED感染的发生率无显着差异（分别为2.8％和1.3％；无显着性）。然而，新近感染的患者的院内死亡率比未新感染的患者高（分别为22.2％和0.9％； P <0.05）。在多因素分析中，院内死亡率的预测因素是CIED植入前的近期感染（几率：20.3； 95％置信区间：8.4-49.3； P <0.001）和终末期肾脏疾病（4.3; 1.4-12.8； P = 0.009）。结论如果患者是高热的并且已经接受了足够的抗生素治疗时间，那么CIED植入对于近期感染的患者是可行的。