Inclusion body myositis (IBM) is a slowly progressive and heterogeneous disorder that is a challenge for measuring clinical trial efficacy. The current methods of measuring progression of the disease utilizes the Inclusion Body Myositis Functional Rating Scale, grip strength by dynamometer, and finger flexor strength. One of the hallmarks of the disease is selective deep finger flexor weakness. To date, no adequate data has been available to determine how well the Functional Rating Scale relates to this hallmark physical exam deficit. Our study is the first to investigate the degree of correlation between items pertaining to hand function in the Functional Rating Scale with measured grip and finger flexor strength in IBM patients. We have found a lower than expected correlation with finger flexor strength and even lower with grip strength. The current Functional Rating Scale will benefit from optimization to measure clinical progression more accurately.

中文翻译：

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包涵体肌炎手功能的横断面研究——对功能评定量表的影响

包涵体肌炎 (IBM) 是一种缓慢进展的异质性疾病，是衡量临床试验疗效的挑战。当前测量疾病进展的方法利用包涵体肌炎功能评定量表、测力计的握力和手指屈肌强度。该疾病的标志之一是选择性的深手指屈肌无力。迄今为止，还没有足够的数据来确定功能评定量表与这一标志性体检缺陷的相关程度。我们的研究是第一个调查功能评定量表中与手部功能相关的项目与 IBM 患者测量的握力和手指屈肌强度之间的相关程度的研究。我们发现与手指屈肌强度的相关性低于预期，与握力的相关性甚至更低。