First azole‐resistant Aspergillus fumigatus isolates with the environmental TR 46 /Y121F/ T289A mutation in Iran,Mycoses

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First azole‐resistant Aspergillus fumigatus isolates with the environmental TR 46 /Y121F/ T289A mutation in Iran
Mycoses ( IF 4.1 ) Pub Date : 2020-03-13 , DOI: 10.1111/myc.13064
Fatemeh Ahangarkani _{1,

2} , Ynze Puts ₂ , Mojtaba Nabili ₃ , Sadegh Khodavaisy ₄ , Maryam Moazeni _{5,

6} , Zahra Salehi ₇ , Melika Laal Kargar ₇ , Hamid Badali _{5,

6,

8} , Jacques F Meis _{2,

9}

Affiliation

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Department of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran.
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
ECMM Excellence Center for Medical Mycology, Centre of Expertise in Mycology Radboudumc, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

Azole resistance in Aspergillus fumigatus is an emerging problem and reported from all continents. As triazole antifungals are the mainstay of therapy in the management of invasive aspergillosis, azole‐resistant A fumigatus has become a major medical concern and with complicated clinical management.

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