T1-Weighted Intensity Increase After a Single Administration of a Linear Gadolinium-Based Contrast Agent in Multiple Sclerosis,Clinical Neuroradiology

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T1-Weighted Intensity Increase After a Single Administration of a Linear Gadolinium-Based Contrast Agent in Multiple Sclerosis
Clinical Neuroradiology ( IF 2.4 ) Pub Date : 2020-02-13 , DOI: 10.1007/s00062-020-00882-6
S Grahl _{1,

2} , M Bussas _{1,

2} , V Pongratz _{1,

2} , J S Kirschke ₃ , C Zimmer ₃ , A Berthele ₁ , B Hemmer _{1,

4} , M Mühlau _{1,

2}

Affiliation

Purpose

Through analysis of T1-weighted (T1w) images this study investigated gadolinium (Gd) deposition in the brain after administration of a linear (gadopentetic acid) and a cyclic (gadoteric acid) gadolinium-based contrast agent (GBCA) in patients with multiple sclerosis (MS), a disorder frequently requiring magnetic resonance imaging (MRI) scans over years.

Methods

A total of 3233 T1w images (unenhanced with respect to the same scanning session) of 881 MS patients were retrospectively analyzed. After spatial normalization and intensity scaling using a sphere within the pons, differences of all pairs of subsequent scans were calculated and attributed to either linear (n = 2718) or cyclic (n = 385) or no GBCA (n = 130) according to the first scan. Regional analyses were performed, focusing on the dentate nucleus, and whole brain analyses. By 1‑sample t‑tests, signal intensity increases within conditions were searched for; conditions were compared by 2‑sample t‑tests. Furthermore, recent hypotheses on the reversibility of GBCA deposition were tested.

Results

In the dentate nucleus, a significant increase was observed only after administration of linear GBCA even after a single GBCA administration. This increase differed significantly (p < 0.001) from the other conditions (cyclic and no GBCA). Whole brain analyses revealed T1w signal increases only after administration of linear GBCA within two regions, the dentate nucleus and globus pallidus. Additional analyses did not indicate any decline of Gd deposition in the brain.

Conclusion

The data point towards Gd deposition in the brain after administration of linear GBCA even after a single administration.

中文翻译：

在多发性硬化症中单次使用线性钆造影剂后 T1 加权强度增加

目的

通过对 T1 加权 (T1w) 图像的分析，本研究调查了多发性硬化症患者在使用线性（钆喷酸）和环状（钆酸）钆造影剂 (GBCA) 后脑中的钆 (Gd) 沉积(MS)，一种多年来经常需要磁共振成像 (MRI) 扫描的疾病。

方法

回顾性分析了 881 名 MS 患者的总共 3233 张 T1w 图像（在同一扫描阶段未增强）。空间标准化，并使用脑桥内的球体强度缩放之后，计算归属所有对随后的扫描中的差异是线性（Ñ  = 2718）或环状（ñ  = 385）或无GBCA（Ñ 根据= 130）初次扫描。进行了区域分析，重点是齿状核和全脑分析。通过 1 样本 t 检验，搜索条件内的信号强度增加；条件通过 2 样本 t 检验进行比较。此外，还测试了最近关于 GBCA 沉积可逆性的假设。

结果

在齿状核中，即使在单次 GBCA 给药后，也仅在给药线性 GBCA 后观察到显着增加。这种增加与 其他条件（循环和无 GBCA）显着不同（p < 0.001）。全脑分析显示，只有在齿状核和苍白球这两个区域内施用线性 GBCA 后，T1w 信号才会增加。额外的分析没有表明大脑中 Gd 沉积的任何下降。