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The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction
Frontiers in Systems Neuroscience ( IF 3.1 ) Pub Date : 2020-01-28 , DOI: 10.3389/fnsys.2020.00003
Hans C Lou 1 , Kristine Rømer Thomsen 2 , Jean-Pierre Changeux 3
Affiliation  

The electrophysiology of the paralimbic network (“default mode”) for self-awareness has drawn much attention in the past couple of decades. In contrast, knowledge of the molecular organization of conscious experience has only lately come into focus. We here review newer data on dopaminergic control of awareness in humans, particularly in self-awareness. These results implicate mainly dopaminergic neurotransmission and the control of GABAergic function directly in the paralimbic network. The findings are important for understanding addiction, developmental disorders, and dysfunctional consciousness.

中文翻译:

自我意识的分子组织:旁边缘多巴胺-GABA 相互作用

在过去的几十年里,用于自我意识的旁边缘网络(“默认模式”)的电生理学引起了很多关注。相比之下,意识体验的分子组织知识直到最近才成为焦点。我们在这里回顾了关于人类意识的多巴胺能控制的新数据,特别是在自我意识方面。这些结果主要涉及多巴胺能神经传递和直接在旁边缘网络中控制 GABA 能功能。这些发现对于理解成瘾、发育障碍和意识障碍很重要。
更新日期:2020-01-28
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