BACKGROUND Many control methods have been implemented to tackle onchocerciasis and great successes have been achieved, leading to a paradigm shift from control of morbidity to interruption of transmission and ultimately elimination. The mandate of the African Programme for Onchocerciasis Control (APOC) ended in 2015, and endemic countries are to plan and conduct elimination activities by themselves, with technical assistance by the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN). To this end, an elimination expert committee was set up in Cameroon in 2018. This committee identified the need to update the data on the current situation of onchocerciasis. The present study aims to systematically review and report all available epidemiological data, including prevalence, intensity and transmission of onchocerciasis to provide pertinent information that will be useful to design optimal strategies to achieve onchocerciasis elimination in Cameroon. METHODS PubMed/MEDLINE, EMBASE and Web of Science will be searched from inception onwards. Grey literature will be identified through Google Scholar searches, dissertation databases and other relevant documents such as government reports. Eligible studies will be mostly observational, including cohort and cross-sectional surveys. No limitations will be imposed on publication status and study period. The primary outcomes will be (1) the prevalence and intensity of Onchocerca volvulus infection in humans, (2) transmission intensity and (3) impact of interventions on prevalence, intensity and transmission of onchocerciasis. Secondary outcomes will be environmental and socio-demographic factors supporting the primary outcomes. Two reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Methodological quality including bias will be appraised using appropriate approaches. A narrative synthesis will describe quality and content of the epidemiological evidence. Prevalence and intensity of infection estimates will be stratified according to gender, age, geographical location and year of publication. DISCUSSION This study will provide the health authorities as well as the scientific community with up-to-date information about the epidemiological situation of onchocerciasis in Cameroon. Understanding the spatiotemporal dynamics of the infection will help to define alternative and complementary strategies to accelerate onchocerciasis elimination in the country. Results of this review will also be used to update existing epidemiological models for onchocerciasis in order to fine-tune predictions of elimination timeframes in the country. SYSTEMATIC REVIEW REGISTRATION This protocol is under registration review in PROSPERO.

中文翻译：

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喀麦隆盘尾丝虫病情况分析：流行病学研究和疾病控制干预措施影响的系统审查方案。

背景技术已经实施了许多控制方法来应对盘尾丝虫病并取得了巨大成功，导致从控制发病率到阻断传播并最终消除的范式转变。非洲盘尾丝虫病控制计划（APOC）的授权于2015年结束，流行国家将在消除被忽视的热带病扩大特别项目（ESPEN）的技术援助下自行规划和开展消除活动。为此，喀麦隆于2018年成立了消除专家委员会。该委员会认为有必要更新盘尾丝虫病现状的数据。本研究旨在系统审查和报告所有可用的流行病学数据，包括盘尾丝虫病的患病率、强度和传播情况，以提供相关信息，有助于设计最佳策略，以在喀麦隆消除盘尾丝虫病。方法 从一开始就将在 PubMed/MEDLINE、EMBASE 和 Web of Science 上进行检索。灰色文献将通过谷歌学术搜索、论文数据库和其他相关文件（例如政府报告）来识别。符合条件的研究主要是观察性的，包括队列和横断面调查。发表状态和研究期限不受限制。主要结果将是（1）人类盘尾丝虫感染的患病率和强度，（2）传播强度和（3）干预措施对盘尾丝虫病患病率、强度和传播的影响。次要结果将是支持主要结果的环境和社会人口因素。两名审稿人将独立筛选所有引文、全文文章和摘要数据。潜在的冲突将通过讨论解决。将使用适当的方法评估包括偏倚在内的方法学质量。叙述性综合将描述流行病学证据的质量和内容。感染流行率和强度估计将根据性别、年龄、地理位置和出版年份进行分层。讨论 这项研究将为卫生当局和科学界提供有关喀麦隆盘尾丝虫病流行病学情况的最新信息。了解感染的时空动态将有助于确定替代和补充策略，以加速该国消除盘尾丝虫病。此次审查的结果还将用于更新现有的盘尾丝虫病流行病学模型，以便微调该国消除时间框架的预测。系统审查注册 该方案正在 PROSPERO 中接受注册审查。