Methamphetamine (meth) can greatly damage the prefrontal cortex of the brain and trigger dysfunction of the cognitive control loop, which triggers not only drug dependence but also emotional disorders. The imbalance between the cognitive and emotional systems will lead to crossmodal emotional deficits. Until now, the negative impact of meth dependence on crossmodal emotional processing has not received attention. Therefore, the present study firstly examined the differences in crossmodal emotional processing between healthy controls and meth dependents (MADs) and then investigated the role of visual- or auditory-leading cues in the promotion of crossmodal emotional processing. Experiment 1 found that MADs made a visual-auditory integration disorder for fearful emotion, which may be related to the defects in information transmission between the auditory and auditory cortex. Experiment 2 found that MADs had a crossmodal disorder pertaining to fear under visual-leading cues, but the fearful sound improved the detection of facial emotions for MADs. Experiment 3 reconfirmed that, for MADs, A-leading cues could induce crossmodal integration immediately more easily than V-leading ones. These findings provided sufficient quantitative indicators and evidences that meth dependence was associated with crossmodal integration disorders, which in turn was associated with auditory-leading cues that enhanced the recognition ability of MADs for complex emotions (all results are available at: https://osf.io/x6rv5/). These results provided a better understanding for individuals using drugs in order to enhance the cognition for the complex crossmodal emotional integration.

中文翻译：

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甲基苯丙胺依赖者情绪预测过程中跨模式整合的促进。

甲基苯丙胺（meth）会极大地损害大脑前额叶皮层，引发认知控制环路功能障碍，这不仅会引发药物依赖，还会引发情绪障碍。认知系统和情感系统之间的不平衡会导致跨模态情感缺陷。到目前为止，冰毒依赖对跨模式情绪处理的负面影响尚未受到关注。因此，本研究首先考察了健康对照者和冰毒依赖者（MAD）之间跨模式情绪处理的差异，然后研究了视觉或听觉引导线索在促进跨模式情绪处理中的作用。实验1发现MADs对恐惧情绪产生视觉听觉整合障碍，这可能与听觉皮层和听觉皮层之间的信息传递缺陷有关。实验2发现MAD在视觉引导线索下存在与恐惧相关的跨模态障碍，但恐惧的声音改善了MAD对面部情绪的检测。实验 3 再次证实，对于 MAD，A 主导的线索比 V 主导的线索更容易立即诱导跨模态整合。这些发现提供了足够的定量指标和证据，证明冰毒依赖与跨模式整合障碍相关，而跨模式整合障碍又与听觉主导线索相关，这些线索增强了 MAD 对复杂情绪的识别能力（所有结果均可在：https://osf .io/x6rv5/)。这些结果为使用药物的个体提供了更好的理解，以增强对复杂的跨模式情感整合的认知。