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Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip.
Developmental Biology ( IF 2.5 ) Pub Date : 2020-02-05 , DOI: 10.1016/j.ydbio.2020.02.002
Camilo Riquelme-Guzmán 1 , Osvaldo Contreras 2
Affiliation  

The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema remain unknown. In an exciting new work, Storer et al. take advantage of single-cell RNAseq combined with Pdgfra+ lineage-tracing to open the way into the enigmatic world of mammalian tissue regeneration.

中文翻译:

单细胞革命揭示了再生的哺乳动物指尖的奥秘。

指尖是研究哺乳动物再生的令人兴奋的模型,但是与胚泡形成和重塑有关的确切机制和细胞数量仍然未知。在一项激动人心的新工作中,Storer等人。利用单细胞RNAseq与Pdgfra +谱系追踪相结合的优势,为进入神秘的哺乳动物组织再生世界开辟了道路。
更新日期:2020-04-20
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