BACKGROUND Recently, urine protein:creatinine ratios (UPC) were shown to be lower in urine samples from dogs collected at home (AH) as compared to those collected in hospital (IH). Stress-inducing procedures and travel to the hospital have been hypothesized to cause prerenal proteinuria. OBJECTIVES Evaluate patient stress using urine cortisol:creatinine ratios (UCCr) and correlate UCCr to UPC in urine samples obtained AH and IH. ANIMALS Thirty-six healthy, client-owned dogs. METHODS Prospective, non-masked study. Two voided urine samples were obtained (AH and IH). Complete urinalysis as well as UPC and UCCr were performed. Clients graded their dogs' stress level AH, in transport, and IH. RESULTS The UCCr was significantly higher in IH samples than in AH samples (P < .0001), but UPC was not significantly different between AH and IH urine samples (P = .14). In all samples and in both collection settings, UCCr was not significantly correlated with UPC. Travel time and time IH were not correlated with change in UCCr or UPC. In 8 dogs with borderline or overt proteinuria, no significant difference was found in UPC between settings, but UCCr was significantly higher in IH samples. CONCLUSIONS AND CLINICAL IMPORTANCE The UPC was not higher when measured in urine samples collected IH compared to AH. Dogs had higher UCCr IH, but UCCr was not associated with UPC. Stress, as estimated by UCCr, did not affect proteinuria. Further evidence is needed to support the claim that stress may result in proteinuria in healthy dogs.

中文翻译：

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在家和医院收集的健康狗尿液样本中尿皮质醇-肌酐和蛋白质-肌酐的比率。

背景技术近来，与从医院（IH）收集的狗相比，在家中（AH）收集的狗的尿液样本中的尿蛋白：肌酐比率（UPC）显示较低。据推测，诱发压力的程序和去医院可导致肾前蛋白尿。目的使用尿皮质醇：肌酐比率（UCCr）评估患者的压力，并将AHCr和IH尿液样本中的UCCr与UPC相关联。动物36只健康的，由客户拥有的狗。方法前瞻性，非掩盖性研究。获得了两个排尿样品（AH和IH）。进行了完整的尿液分析以及UPC和UCCr。客户在运输和IH中将狗的压力等级定为AH。结果IH样品中的UCCr显着高于AH样品（P <.0001），但是AH和IH尿液样本之间的UPC没有显着差异（P = .14）。在所有样品中以及在两个收集设置中，UCCr与UPC均无显着相关性。旅行时间和IH时间与UCCr或UPC的变化无关。在有边界蛋白尿或明显蛋白尿的8只狗中，UPC的设置之间无显着差异，但IH样品中的UCCr显着更高。结论和临床意义与AH相比，在IH收集的尿液样品中测得的UPC并不高。狗的UCCr IH较高，但UCCr与UPC无关。UCCr估计，压力不会影响蛋白尿。需要进一步的证据来证明压力可能导致健康犬出现蛋白尿的说法。UCCr与UPC没有显着相关。行程时间和IH时间与UCCr或UPC的变化无关。在有边界蛋白尿或明显蛋白尿的8只狗中，UPC的设置之间无显着差异，但IH样品中的UCCr显着更高。结论和临床意义与AH相比，在IH收集的尿液样品中测得的UPC并不高。狗的UCCr IH较高，但UCCr与UPC无关。UCCr估计，压力不会影响蛋白尿。需要进一步的证据来证明压力可能导致健康犬出现蛋白尿的说法。UCCr与UPC没有显着相关。旅行时间和IH时间与UCCr或UPC的变化无关。在有边界蛋白尿或明显蛋白尿的8只狗中，UPC的设置之间无显着差异，但IH样品中的UCCr显着更高。结论和临床意义在尿液中测量的UPC与AH相比，UPC并不高。狗的UCCr IH较高，但UCCr与UPC无关。UCCr估计，压力不会影响蛋白尿。需要进一步的证据来证明压力可能导致健康犬出现蛋白尿的说法。结论和临床意义与AH相比，在IH收集的尿液样品中测得的UPC并不高。狗的UCCr IH较高，但UCCr与UPC无关。UCCr估计，压力不会影响蛋白尿。需要进一步的证据来证明压力可能导致健康犬出现蛋白尿的说法。结论和临床意义与AH相比，在IH收集的尿液样品中测得的UPC并不高。狗的UCCr IH较高，但UCCr与UPC无关。UCCr估计，压力不会影响蛋白尿。需要进一步的证据来证明压力可能导致健康犬出现蛋白尿的说法。