Micronutrient supplementation during pregnancy has been shown to be a cost‐effective method to reduce the risk of adverse pregnancy and birth outcomes. However, one of the main barriers to the successful implementation of a micronutrient supplementation program in pregnancy is poor adherence. Our review will assess the effectiveness of interventions designed to increase adherence to micronutrient supplements in pregnancy. Following the Cochrane Collaboration Methodology, we will start by conducting the literature searches on Medline (via PubMed), Embase, Scopus, Web of Science, and Cochrane Library, in addition to sources of gray literature, to retrieve all the available relevant studies. We will include randomized controlled trials and nonrandomized studies with a control group, where participants are pregnant women taking any micronutrient supplements in the context of antenatal care globally. We will include studies with targeted interventions designed to improve adherence to micronutrient supplementation in pregnant women compared with (1) usual care or no intervention or (2) other targeted micronutrient adherence intervention. Abstract selection, data extraction, and risk of bias assessment (according to the type of studies) will be conducted by two independent reviewers. The pooled results will be reported using the standardized mean differences for continuous data, and odds ratio or risk ratio for dichotomous data. We will assess sources of heterogeneity and publication bias. By following this protocol, we will systematically assess and synthesize the existing evidence about interventions designed to increase adherence to micronutrient supplementation in pregnant women. Understanding which strategies are more effective to increase the consumption of micronutrient supplements during this critical stage of life will have significant implications for clinicians and policymakers involved in the delivery of prenatal micronutrient supplementation interventions.

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增加孕期补充微量营养素依从性的干预措施：系统评价方案

孕期补充微量营养素已被证明是降低不良妊娠和分娩结局风险的一种经济有效的方法。然而，成功实施妊娠期微量营养素补充计划的主要障碍之一是依从性差。我们的审查将评估旨在增加妊娠期微量营养素补充剂依从性的干预措施的有效性。遵循 Cochrane 协作方法，我们将首先在 Medline（通过 PubMed）、Embase、Scopus、Web of Science 和 Cochrane 图书馆进行文献搜索，以及灰色文献来源，以检索所有可用的相关研究。我们将包括随机对照试验和具有对照组的非随机研究，参与者是在全球产前保健中服用任何微量营养素补充剂的孕妇。我们将纳入旨在提高孕妇补充微量营养素依从性与 (1) 常规护理或不干预或 (2) 其他有针对性的微量营养素依从性干预相比的针对性干预研究。摘要选择、数据提取和偏倚风险评估（根据研究类型）将由两名独立审查员进行。汇总结果将使用连续数据的标准化平均差和二分类数据的优势比或风险比报告。我们将评估异质性和发表偏倚的来源。通过遵循此协议，我们将系统地评估和综合有关旨在提高孕妇补充微量营养素依从性的干预措施的现有证据。了解哪些策略可以更有效地在生命的这个关键阶段增加微量营养素补充剂的消费，将对参与提供产前微量营养素补充剂干预措施的临床医生和决策者产生重大影响。