With the high pervasiveness of viral diseases, the battle against viruses has never ceased. Here we discuss five cellular processes, namely "autophagy", "programmed cell death", "immune response", "cell cycle alteration", and "lipid metabolic reprogramming", that considerably guide viral replication after host infection in an orchestrated manner. On viral infection, "autophagy" and "programmed cell death" are two dynamically synchronized cell survival programs; "immune response" is a cell defense program typically suppressed by viruses; "cell cycle alteration" and "lipid metabolic reprogramming" are two altered cell housekeeping programs tunable in both directions. We emphasize on their functionalities in modulating viral replication, strategies viruses have evolved to tune these processes for their benefit, and how these processes orchestrate and govern cell fate upon viral infection. Understanding how viruses hijack host networks has both academic and industrial values in providing insights toward therapeutic strategy design for viral disease control, offering useful information in applications that aim to use viral vectors to improve human health such as gene therapy, and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.

中文翻译：

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主机网络劫持方面的协调工作：控制病毒复制的过程。

随着病毒性疾病的高度普及，与病毒的斗争从未停止。在这里，我们讨论了五个细胞过程，即“自噬”，“程序性细胞死亡”，“免疫应答”，“细胞周期改变”和“脂质代谢重编程”，它们以协调的方式大大指导了宿主感染后的病毒复制。对于病毒感染，“自噬”和“程序性细胞死亡”是两个动态同步的细胞存活程序；“免疫应答”是通常被病毒抑制的细胞防御程序；“细胞周期改变”和“脂质代谢重编程”是两个可在两个方向上调节的改变的细胞看家程序。我们强调它们在调节病毒复制中的功能，策略病毒已经进化为调整这些过程以使其受益，以及这些过程如何协调和控制病毒感染后的细胞命运。了解病毒劫持主机网络在提供有关病毒性疾病控制的治疗策略设计的见解，在旨在使用病毒载体改善人类健康的应用（例如基因治疗）的应用程序中提供有用的信息以及提供最大程度地利用病毒的指南方面具有学术和工业价值颗粒产量可降低疫苗生产成本。