Abstract

Hypertension is commonly a quiet condition, and it expands the risk of heart diseases and stroke. Calcium delivers a substantial role in cardiovascular functions and hence is essential for cardiac automaticity and functioning. Calcium channel antagonists are the choice of drugs for the management of cardiovascular diseases; they precisely stop the introduction of calcium through L-type calcium channels are existing channels in the heart. Cilnidipine belongs to the class 4th generation calcium channel blockers as a foremost therapeutic agent used in the treatment of hypertension and heart diseases. This review article focuses on an inclusive account of crucial analytical methodologies used for the pharmaceutical analysis of cilnidipine in pure forms, biological samples and pharmaceuticals. According to literature reports several analytical techniques such as hyphenated techniques, high-performance thin-layer chromatography, high-performance liquid-chromatography, capillary electrophoresis, voltammetry, UV/Vis-spectrophotometry, and Fourier-transform infrared spectroscopy approaches have been used for determination of cilnidipine alone or in the combined dosage form. We have also discussed the pharmacopeial assay methods, physicochemical properties, and also depict the stacked column chart for year wise publication count for cilnidipine. From literature, concluded that the high-performance liquid-chromatography and UV/Vis-spectrophotometry methods are the most prevailing methods for the analysis of cilnidipine. The data presented in this review may provide a very significant base for further studies on cilnidipine in the area of drug analysis.

摘要

高血压通常是一种安静的疾病，它会增加患心脏病和中风的风险。钙在心血管功能中发挥重要作用，因此对心脏的自动性和功能至关重要。钙通道拮抗剂是治疗心血管疾病的首选药物；它们正是通过 L 型钙通道阻止钙的引入，这些通道是心脏中现有的通道。西尼地平属于第四代钙通道阻滞剂，是治疗高血压和心脏病的首要治疗剂。这篇评论文章重点介绍了用于纯形式、生物样品和药物的西尼地平药物分析的关键分析方法。根据文献报道，几种分析技术，如联用技术、高效薄层色谱、高效液相色谱、毛细管电泳、伏安法、紫外/可见分光光度法和傅里叶变换红外光谱方法已被用于测定西尼地平单独或联合剂型。我们还讨论了药典测定方法、理化特性，并描绘了西尼地平年度出版计数的堆积柱状图。从文献中得出结论，高效液相色谱法和紫外/可见分光光度法是分析西尼地平最常用的方法。