OBJECTIVE To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS). METHODS Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0.4 g/kg every 14 days for a total of 5 infusions. After 3 months, standard uptake value ratio (SUVR) and amyloid retinal deposits were reassessed. RESULTS Three subjects had a reduction in amyloid SUVR and all 5 subjects had a reduction in amyloid retinal deposits in at least 1 eye. CONCLUSIONS A short course of IVIG over 2 months removes a measurable amount of amyloid from the CNS in persons with MCI.

中文翻译：

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使用 IVIG 治疗轻度认知障碍后，大脑和视网膜中的淀粉样蛋白减少。


目的 评估轻度认知障碍 (MCI) 受试者静脉注射免疫球蛋白 (IVIG) 是否会导致中枢神经系统 (CNS) 淀粉样蛋白减少。方法 5 名患有 MCI 的受试者接受了基线氟贝吡正电子发射断层扫描和视网膜自发荧光成像。所有患者每 14 天按 0.4 g/kg 注射 IVIG（Octagam 10%），总共 5 次输注。 3个月后，重新评估标准摄取值比（SUVR）和淀粉样蛋白视网膜沉积。结果 3 名受试者的淀粉样蛋白 SUVR 减少，所有 5 名受试者至少 1 只眼睛的淀粉样蛋白视网膜沉积物减少。结论 2 个月以上的短期 IVIG 疗程可以从 MCI 患者的 CNS 中去除可测量量的淀粉样蛋白。