Objective: Nowadays, retinal microvascular structures can be investigated using optical coherence tomography angiography (OCTA). We aimed to evaluate the probable vascular changes in the foveal and peripapillary regions of patients with multiple sclerosis (MS).Methods: A total of 20 patients with relapsing remitting multiple sclerosis (RRMS) and 24 healthy controls were recruited in this study. All participants' superficial and deeper retinal and peripapillary layers were evaluated using OCTA after a total ophthalmologic examination.Results: In the superficial plexus, the whole image (49.53 ± 3.9% and 51.83 ± 2.1%, p = 0.009), superior hemisphere (49.44 ± 4.11% and 51.63 ± 2.3%, p = 0.018), inferior hemisphere (49.75 ± 3.9% and 52.03 ± 2.2%, p = 0.012), parafoveal (51.87 ± 3.9% and 53.08 ± 3.46%, p = 0.048) and perifoveal (50.41 ± 3.86% and 52.76 ± 2.1%, p = 0.007) vascular densities were statistically significant lesser in patients with RRMS than in controls. In the optic disc OCTA parameters, the vessel density of the inferior (50.15 ± 6.99% and 53.04 ± 3.63% p = 0.043) and temporal sector (48.09 ± 5.47% and 50.85 ± 5.24%, p = 0.045) were statistically significantly lesser in patients with RRMS than in controls.Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS.

中文翻译：

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光学相干断层扫描血管造影发现多发性硬化伴或不伴视神经炎。

目的：如今，可以使用光学相干断层扫描血管造影（OCTA）研究视网膜微血管结构。我们旨在评估多发性硬化症（MS）患者的中央凹和乳突周围区域可能的血管变化。方法：本研究共招募了20例复发缓解型多发性硬化症（RRMS）患者和24名健康对照。全部受试者接受眼科检查后，使用OCTA对所有参与者的浅层和较深的视网膜和乳头周围层进行了评估。结果：在浅神经丛中，整个图像（49.53±3.9％和51.83±2.1％，p = 0.009），上半球（49.44） ±4.11％和51.63±2.3％，p = 0.018），下半球（49.75±3.9％和52.03±2.2％，p = 0.012），中央凹（51.87±3.9％和53.08±3.46％，p = 0.048）和中央凹（50.41±3.86％和52。76±2.1％，p = 0.007）RRMS患者的血管密度在统计学上显着低于对照组。在光盘OCTA参数中，下颌血管密度（50.15±6.99％和53.04±3.63％p = 0.043）和颞侧血管密度（48.09±5.47％和50.85±5.24％，p = 0.045）在统计学上显着降低结论：本研究中显示的RRMS患者视网膜或乳头周围区域血管密度的降低应进一步研究，以确定其是视神经炎的继发性病变还是原发性血管病变MS的状况。