Renal cell carcinoma with sarcomatoid differentiation (RCCs) is rare, accounting for 1-8% of all RCC histological subtypes. In this study, we examined 139 patients with RCCs and aimed to explore their clinicopathologic features and prognostic factors. From January 2007 to January 2019, patients who were pathologically diagnosed with RCCs were included in this retrospective study. Data on clinicopathologic features and overall survival were collected. The expression of CK, vimentin, CK7, and CD10 in the sarcomatoid regions of RCCs was detected. The Kaplan-Meier curves and log-rank tests were used to describe the effect of clinicopathologic characteristics on overall survival. A Cox regression model was used to evaluate risk factors for prognosis. A total of 139 patients with RCCs were identified. The median age at diagnosis was 60 years. The median survival time of all patients was 39 months. The three- and five-year survival rates were 50.2% and 44.0%, respectively. A high pathologic T stage (pT3 and pT4), microvascular invasion, and lymph node metastasis were significant predictors of prognosis. Pathologic T4 stage and lymph node metastasis were independent prognostic factors for overall survival in patients with RCCs. Furthermore, the expression of CD10 was a prognostic factor for overall survival. In this study, a relatively large cohort of patients with RCCs was analyzed. We summarized the clinicopathologic features of RCCs and explored the risk factors for prognosis. Our findings may provide valuable prediction for clinical strategy.

中文翻译：

---

肉瘤样分化的肾细胞癌患者的临床病理特征和预后因素。

具有肉瘤样分化（RCC）的肾细胞癌很少见，占所有RCC组织学亚型的1-8％。在这项研究中，我们检查了139例RCC患者，旨在探讨其临床病理特征和预后因素。从2007年1月至2019年1月，在这项回顾性研究中纳入了经病理诊断为RCC的患者。收集有关临床病理特征和总体生存率的数据。检测到RCC的肉瘤样区域中CK，波形蛋白，CK7和CD10的表达。Kaplan-Meier曲线和对数秩检验用于描述临床病理特征对总体生存的影响。使用Cox回归模型评估预后的危险因素。总共鉴定出139例RCC患者。诊断时的中位年龄为60岁。所有患者的中位生存时间为39个月。三年和五年生存率分别为50.2％和44.0％。高病理T分期（pT3和pT4），微血管浸润和淋巴结转移是预后的重要预测指标。病理T4期和淋巴结转移是RCC患者总体生存的独立预后因素。此外，CD10的表达是整体生存的预后因素。在这项研究中，分析了相对较大的RCC患者队列。我们总结了RCC的临床病理特征并探讨了预后的危险因素。我们的发现可能为临床策略提供有价值的预测。高病理T分期（pT3和pT4），微血管浸润和淋巴结转移是预后的重要预测指标。病理T4期和淋巴结转移是RCC患者总体生存的独立预后因素。此外，CD10的表达是整体生存的预后因素。在这项研究中，分析了相对较大的RCC患者队列。我们总结了RCC的临床病理特征并探讨了预后的危险因素。我们的发现可能为临床策略提供有价值的预测。高病理T分期（pT3和pT4），微血管浸润和淋巴结转移是预后的重要预测指标。病理T4期和淋巴结转移是RCC患者总体生存的独立预后因素。此外，CD10的表达是整体生存的预后因素。在这项研究中，分析了相对较大的RCC患者队列。我们总结了RCC的临床病理特征并探讨了预后的危险因素。我们的发现可能为临床策略提供有价值的预测。CD10的表达是整体生存的预后因素。在这项研究中，分析了相对较大的RCC患者队列。我们总结了RCC的临床病理特征并探讨了预后的危险因素。我们的发现可能为临床策略提供有价值的预测。CD10的表达是整体生存的预后因素。在这项研究中，分析了相对较大的RCC患者队列。我们总结了RCC的临床病理特征并探讨了预后的危险因素。我们的发现可能为临床策略提供有价值的预测。