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Neuropeptide Y in PTSD, MDD, and chronic stress: A systematic review and meta-analysis.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-02-11 , DOI: 10.1002/jnr.24589 Umit Tural 1 , Dan V Iosifescu 1, 2
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-02-11 , DOI: 10.1002/jnr.24589 Umit Tural 1 , Dan V Iosifescu 1, 2
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Previous studies have suggested that neuropeptide Y (NPY) levels may be altered in patients with major depressive disorder (MDD), post-traumatic stress disorder (PTSD) and chronic stress. We investigated, through systematic review and meta-analysis, whether the mean levels of NPY are significantly different in patients with MDD, PTSD or chronic stress, compared to controls. The main outcome was the pooled standardized mean difference (SMD) with 95% confidence intervals between cases and controls, using the random-effects model. Heterogeneity and publication bias were evaluated. Thirty-five studies met eligibility criteria. Meta-regression determined that medication and sex could explain 27% of the between-study variance. Females and participants currently prescribed psychotropic medications had significantly higher levels of NPY. NPY levels were significantly lower in plasma and cerebrospinal fluid (CSF) in PTSD patients versus controls. Patients with MDD had significantly lower levels of NPY in plasma compared to controls, but not in the CSF. The magnitudes of the decrease in plasma NPY levels were not significantly different between PTSD and MDD. However, chronic stress patients had significantly higher plasma NPY levels compared to controls, PTSD or MDD. Our findings may imply a shared role of NPY in trauma and depression: nevertheless, it is not clear that the association is specific to these disorders. Psychotropic medications may help restore NPY levels. Further controlled studies are needed to better delineate the contribution of confounding variables such as type of depression, body mass index, appetite or sleep architecture.
中文翻译：
PTSD，MDD和慢性应激中的神经肽Y：系统评价和荟萃分析。
先前的研究表明，患有重度抑郁症（MDD），创伤后应激障碍（PTSD）和慢性应激的患者可能会改变神经肽Y（NPY）的水平。通过系统的回顾和荟萃分析，我们调查了与对照组相比，MDD，PTSD或慢性应激患者的NPY平均水平是否显着不同。主要结果是使用随机效应模型在病例和对照之间具有95％置信区间的合并标准均值差（SMD）。评价了异质性和出版偏见。三十五项研究符合资格标准。荟萃回归确定，药物和性别可以解释研究之间差异的27％。目前开了精神药物的女性和参与者的NPY水平明显较高。与对照组相比，PTSD患者的血浆和脑脊液（CSF）中的NPY水平显着降低。与对照组相比，MDD患者血浆中的NPY水平显着降低，而CSF中则没有。PTSD和MDD之间血浆NPY水平下降的幅度没有显着差异。但是，与对照组，PTSD或MDD相比，慢性应激患者的血浆NPY水平明显更高。我们的发现可能暗示NPY在创伤和抑郁症中起着共同的作用：尽管如此，尚不清楚这种联系是否与这些疾病有关。精神药物可能有助于恢复NPY水平。需要进行进一步的对照研究，以更好地描述混杂变量的影响，例如抑郁症的类型，体重指数，食欲或睡眠结构。
更新日期：2020-02-11
中文翻译：
PTSD，MDD和慢性应激中的神经肽Y：系统评价和荟萃分析。
先前的研究表明，患有重度抑郁症（MDD），创伤后应激障碍（PTSD）和慢性应激的患者可能会改变神经肽Y（NPY）的水平。通过系统的回顾和荟萃分析，我们调查了与对照组相比，MDD，PTSD或慢性应激患者的NPY平均水平是否显着不同。主要结果是使用随机效应模型在病例和对照之间具有95％置信区间的合并标准均值差（SMD）。评价了异质性和出版偏见。三十五项研究符合资格标准。荟萃回归确定，药物和性别可以解释研究之间差异的27％。目前开了精神药物的女性和参与者的NPY水平明显较高。与对照组相比，PTSD患者的血浆和脑脊液（CSF）中的NPY水平显着降低。与对照组相比，MDD患者血浆中的NPY水平显着降低，而CSF中则没有。PTSD和MDD之间血浆NPY水平下降的幅度没有显着差异。但是，与对照组，PTSD或MDD相比，慢性应激患者的血浆NPY水平明显更高。我们的发现可能暗示NPY在创伤和抑郁症中起着共同的作用：尽管如此，尚不清楚这种联系是否与这些疾病有关。精神药物可能有助于恢复NPY水平。需要进行进一步的对照研究，以更好地描述混杂变量的影响，例如抑郁症的类型，体重指数，食欲或睡眠结构。
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