Parkinson's disease (PD) is the most common movement neurodegenerative disorder. Although our understanding of the underlying mechanisms of pathogenesis in PD has greatly expanded, this knowledge thus far has failed to translate into disease‐modifying therapies. Therefore, it is of the utmost urgency to interrogate further the multifactorial etiology of PD. DNA repair defects cause many neurodegenerative diseases. An exciting new PD research avenue is the role that DNA damage and repair may play in neuronal death. The goal of this mini‐review was to discuss the evidence for the types of DNA damage that accumulates in PD, which has provided clues for which DNA repair pathways, such as DNA double‐strand break repair, are dysfunctional. We further highlight compelling data for activation of the DNA damage response in familial and idiopathic PD. The significance of DNA damage and repair is emerging in the PD field and linking these insights to PD pathogenesis may provide new insights into PD pathophysiology and consequently lead to new therapies.

中文翻译：

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帕金森病中的 DNA 损伤和修复：最新进展和新机遇。

帕金森病 (PD) 是最常见的运动神经退行性疾病。尽管我们对 PD 发病机制的潜在机制的理解已大大扩展，但迄今为止，这些知识未能转化为疾病修饰疗法。因此，进一步探讨 PD 的多因素病因迫在眉睫。DNA 修复缺陷会导致许多神经退行性疾病。一个令人兴奋的新 PD 研究途径是 DNA 损伤和修复可能在神经元死亡中发挥的作用。本次小型综述的目的是讨论 PD 中积累的 DNA 损伤类型的证据，这为 DNA 修复途径（如 DNA 双链断裂修复）功能失调提供了线索。我们进一步强调了在家族性和特发性 PD 中激活 DNA 损伤反应的令人信服的数据。