A testable molecular proposal for the effects of acidosis on skeletal and cardiac muscle is presented. It is based on fluorescence studies published in 1974, which provided evidence for carboxylates in an EF-hand Ca2+ binding site having an abnormal pKa. This results in an H+-bound Blocked substate in the 3-state model of muscle regulation whose contribution inhibits myosin binding in the pH 7 to 6 range. A schematic cartoon illustrates the substate within the 3-state model.

中文翻译：

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酸中毒肌肉功能减弱的分子基础：一项提议。

提出了酸中毒对骨骼肌和心肌影响的可测试分子提议。它基于 1974 年发表的荧光研究，该研究为 EF-hand Ca2+ 结合位点中的羧酸盐具有异常 pKa 提供了证据。这导致在肌肉调节的 3 态模型中产生 H+ 结合的 Blocked 亚状态，其贡献抑制了 pH 7 至 6 范围内的肌球蛋白结合。示意图说明了三态模型中的子状态。