BACKGROUND Pancreatic atrophy as a finding of chronic pancreatitis has largely been a subjective finding. Cross-sectional imaging should provide a means to quantify pancreatic atrophy. OBJECTIVE The purposes of this study were to: (1) quantify pancreatic volume by magnetic resonance imaging (MRI) in a cohort of children without pancreatic disease, (2) define predictors of pancreatic volume and (3) assess the relationship between pancreatic volume and pancreatic fluid secretion. MATERIALS AND METHODS This study involved further analysis of data collected as part of an institutional review board-approved prospective study of secreted fluid volume in response to secretin in 50 healthy children ages 6-16 years. The pancreas was manually segmented on axial MR images to calculate pancreatic volume. Pearson correlation or the Student's t-test were used to define associations between pancreatic volume and patient characteristics and previously calculated secreted fluid volume. Quantile regression was used to define the 5th percentile for pancreatic volume based on body surface area (BSA) [1]. RESULTS Mean pancreatic volume was 46.0±18.8 mL with no significant difference based on sex (boys: 42.4±19 mL, girls: 49.1±18.3 mL, P=0.21). Pancreatic volume was moderately correlated with age (r=0.51, P=0.002) and strongly correlated with BSA (r=0.75, P<0.0001), with the 5th percentile for pancreatic volume defined by: (24.66×BSA) - 4.97. Pancreatic volume was moderately correlated with volume of fluid secreted after secretin administration (r=0.51, P=0.0002). CONCLUSION We report increasing pancreatic volumes by MRI during childhood in a cohort of children without pancreatic disease. We have also shown that pancreatic volume is associated with secreted fluid volume as measured by MRI.

中文翻译：

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健康的胰腺实质体积及其与外分泌功能的关系。

背景技术作为慢性胰腺炎的发现，胰腺萎缩很大程度上是主观的发现。横截面成像应提供量化胰腺萎缩的手段。目的本研究的目的是：（1）通过磁共振成像（MRI）量化无胰腺疾病患儿的胰腺体积，（2）定义胰腺体积的预测因子，（3）评估胰腺体积与胰腺体积之间的关系。胰液分泌。材料与方法这项研究包括对收集的数据进行进一步的分析，这是由机构审查委员会批准的对50岁6至16岁健康儿童的分泌液响应分泌液量的前瞻性研究的一部分。手动在轴向MR图像上分割胰腺以计算胰腺体积。皮尔逊相关性或学生的 s t检验用于定义胰腺体积与患者特征与先前计算的分泌液体积之间的关联。分位数回归用于根据体表面积（BSA）定义胰腺体积的第5个百分位[1]。结果平均胰腺体积为46.0±18.8 mL，性别差异无统计学意义（男孩：42.4±19 mL，女孩：49.1±18.3 mL，P = 0.21）。胰腺体积与年龄呈适度相关（r = 0.51，P = 0.002），与BSA呈强相关（r = 0.75，P <0.0001），胰腺体积的第五个百分位数定义为：（24.66×BSA）-4.97。胰脏体积与促胰液素给药后分泌的体液量呈中等相关性（r = 0.51，P = 0.0002）。结论我们报告了在没有胰腺疾病的儿童队列中，儿童期通过MRI进行的胰腺容积增加。我们还显示，通过MRI测量，胰腺体积与分泌液体积相关。