The long-lasting consequence of a new iodine thyroid blocking strategy (ITB) to be used in case of nuclear accident is evaluated in male Wistar rats using a metabolomics approach applied 30 days after ITB completion. The design used 1 mg/kg/day of KI over 8 days. Thyroid hormones remained unchanged, but there was a metabolic shift measured mainly in thyroid then in plasma and urine. In the thyroid, tyrosine metabolism associated to catecholamine metabolism was more clearly impacted than thyroid hormones pathway. It was accompanied by a peripheral metabolic shift including metabolic regulators, branched-chain amino acids, oxidant stress and inflammation-associated response. Our results suggested that iodide intake can impact gut microbiota metabolism, which was related to host metabolic regulations including in the thyroid. As there were no clear clinical signs of dysfunction or toxicity, we concluded that the measured metabolomics response to the new ITB strategy, especially in thyroid, is unlikely to reveal a pathological condition but a shift towards a new adaptive homeostatic state, called 'allostatic regulation'. The question now is whether or not the shift is permanent and if so at what cost for long-term health. We anticipate our data as a start point for further regulatory toxicity studies.

中文翻译：

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成年雄性大鼠重复给药碘化钾的代谢组学评估。

在雄性Wistar大鼠中，采用代谢组学方法评估ITB完成30天后使用的新的碘甲状腺阻断策略（ITB）的长期结果，以应对核事故。该设计在8天内使用了1 mg / kg /天的KI。甲状腺激素保持不变，但主要在甲状腺中检测到代谢变化，然后在血浆和尿液中检测到。在甲状腺中，与儿茶酚胺代谢有关的酪氨酸代谢比甲状腺激素途径受到更明显的影响。它伴随着周围的代谢变化，包括代谢调节剂，支链氨基酸，氧化应激和炎症相关反应。我们的研究结果表明，碘化物的摄入会影响肠道菌群的代谢，这与宿主的代谢调控（包括甲状腺代谢）有关。由于没有明显的功能障碍或毒性临床迹象，因此我们得出结论，对新的ITB策略（尤其是在甲状腺中）进行的代谢组学测定反应不太可能显示出病理状况，而是向新的适应性稳态状态转变，即“恒流调节” '。现在的问题是，这种转变是否是永久性的，如果是这样，那么长期健康需要付出什么代价。我们预计我们的数据将成为进一步监管毒性研究的起点。现在的问题是，这种转变是否是永久性的，如果是这样，那么长期健康需要付出多少代价。我们预计我们的数据将成为进一步监管毒性研究的起点。现在的问题是，这种转变是否是永久性的，如果是这样，那么长期健康需要付出多少代价。我们预计我们的数据将成为进一步监管毒性研究的起点。