Chronic kidney disease (CKD) and chronic periodontitis (CP) are both common diseases, which are found disproportionately comorbid with each other and have been reported to have a detrimental effect on the progression of each respective disease. They have an overlap in risk factors and both are a source of systemic inflammation along with a wide selection of immunological and non-specific effects that can affect the body over the lifespan of the conditions. Previous studies have investigated the directionality of the relationship between these two diseases; however, there is a lack of literature that has examined how these diseases may be interacting at the localized and systemic level. This review discusses how oral microorganisms have the ability to translocate and have distal effects and provides evidence for microbial involvement in a systemic disease. Furthermore, it summarizes the reported local and systemic effects of CKD and CP and discusses how the interaction of these effects may be responsible for directionality associations reported.

中文翻译：

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探索慢性肾脏疾病和慢性牙周炎之间的假定相互作用。

慢性肾脏疾病（CKD）和慢性牙周炎（CP）都是常见疾病，发现它们彼此比例不相称，并且据报道对每种疾病的进展都有不利影响。它们在危险因素上有重叠，两者都是全身性炎症的源头，并且有广泛的免疫和非特异性作用可供选择，这些作用可在条件的寿命期内影响人体。先前的研究已经调查了这两种疾病之间关系的方向性。但是，缺乏文献来研究这些疾病在局部和系统水平上如何相互作用。这篇综述讨论了口腔微生物如何具有移位能力并具有远端作用，并为微生物参与系统性疾病提供了证据。此外，它总结了已报道的CKD和CP的局部和全身效应，并讨论了这些效应的相互作用如何可能导致所报道的方向性关联。