The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and 90Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence 90Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for 90Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the 90Y detection limit is approximately 3 orders of magnitude higher at 10 µCi.

中文翻译：

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Cerenkov发光和90Y的PET成像：在小动物应用中的能力和局限性。

已经使用组织样小鼠体模和90Y研究了切伦科夫发光成像的体内敏感性极限和量化性能。对于幻影中9mm深的小目标，不存在背景活性，对于使用灵敏CCD相机且无滤镜的2分钟曝光，根据对比度与噪声比确定的Cerenkov发光90Y检测极限为10 nCi。对于定量性能，从图像上感兴趣区域提取的值在直线拟合的5％范围内是线性的，而目标活性为70 nCi及更高。小的分支比随着90Y的正电子发射而衰减，也允许放射性核素的低统计PET成像。对于同一个模型的PET成像，使用基于动物LSO检测器的小型扫描仪，