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Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-02-11 , DOI: 10.1111/lam.13275
Y.‐T. Chen, P.‐S. Hsieh, H.‐H. Ho, S.‐H. Hsieh, Y.‐W. Kuo, S.‐F. Yang, C.‐W. Lin

Probiotics can stabilize gut flora, regulate intestinal immunity and protect the host from enteric diseases; however, their roles in oral health have received little attention compared to their roles in gut health. Nowadays, the prevalence of sugar‐sweetened foods and abuse of antibiotics contribute towards dysbiosis of oral microbiota and drug resistance development in oral pathogens, resulting in various intractable oral diseases. We screened the antibacterial activities of viable and heat‐killed probiotic strains against the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. The probiotic strains Lactobacillus salivarius subsp. salicinius AP‐32, L. rhamnosus CT‐53, L. paracasei ET‐66 and Bifidobacterium animalis subsp. lactis CP‐9 displayed strong antipathogenic activities, whereas heat‐killed AP‐32, CT‐53 and ET‐66 displayed high levels of pathogen inhibition. The antibacterial activities of these probiotics were not associated with their H2O2 production; L. acidophilus TYCA02 produced high levels of H2O2 but merely exhibited moderate antibacterial activities. Oral tablets containing probiotics showed positive inhibitory effects against oral pathogens, particularly those containing viable probiotics. Our results indicate that probiotics prevent the growth of oral pathogens and improve oral health, providing insights into the antipathogenic efficacy of different probiotic species and their potential role in functional foods that improve oral health.

中文翻译:

活的和热灭活的益生菌菌株对口腔病原体的抗菌活性

益生菌可以稳定肠道菌群,调节肠道免疫力,保护宿主免受肠道疾病的侵害;然而,与它们在肠道健康中的作用相比,它们在口腔健康中的作用很少受到关注。如今,含糖食品的盛行和抗生素的滥用导致口腔微生物群失调和口腔病原体耐药性的发展,导致了各种顽固的口腔疾病。我们筛选了活的和热灭活的益生菌菌株对口腔病原体变形链球菌、牙龈卟啉单胞菌、具核梭杆菌和聚集放线菌的抗菌活性。益生菌菌株唾液乳杆菌亚种。salicinius AP-32、鼠李糖乳杆菌 CT-53、副干酪乳杆菌 ET-66 和动物双歧杆菌亚种。乳酸菌 CP-9 表现出很强的抗病原体活性,而热灭活的 AP-32、CT-53 和 ET-66 表现出高水平的病原体抑制作用。这些益生菌的抗菌活性与其产生的 H2O2 无关;L. acidophilus TYCA02 产生高水平的 H2O2,但仅表现出中等的抗菌活性。含有益生菌的口服片剂对口腔病原体显示出积极的抑制作用,尤其是含有活益生菌的那些。我们的研究结果表明,益生菌可以防止口腔病原体的生长并改善口腔健康,从而深入了解不同益生菌种类的抗病原体功效及其在改善口腔健康的功能性食品中的潜在作用。这些益生菌的抗菌活性与其产生的 H2O2 无关;L. acidophilus TYCA02 产生高水平的 H2O2,但仅表现出中等的抗菌活性。含有益生菌的口服片剂对口腔病原体显示出积极的抑制作用,尤其是含有活益生菌的那些。我们的研究结果表明,益生菌可以防止口腔病原体的生长并改善口腔健康,从而深入了解不同益生菌种类的抗病原体功效及其在改善口腔健康的功能性食品中的潜在作用。这些益生菌的抗菌活性与其产生的 H2O2 无关;L. acidophilus TYCA02 产生高水平的 H2O2,但仅表现出中等的抗菌活性。含有益生菌的口服片剂对口腔病原体显示出积极的抑制作用,尤其是含有活益生菌的那些。我们的研究结果表明,益生菌可以防止口腔病原体的生长并改善口腔健康,从而深入了解不同益生菌种类的抗病原体功效及其在改善口腔健康的功能性食品中的潜在作用。含有益生菌的口服片剂对口腔病原体显示出积极的抑制作用,尤其是含有活益生菌的那些。我们的研究结果表明,益生菌可以防止口腔病原体的生长并改善口腔健康,从而深入了解不同益生菌种类的抗病原体功效及其在改善口腔健康的功能性食品中的潜在作用。含有益生菌的口服片剂对口腔病原体显示出积极的抑制作用,尤其是含有活益生菌的那些。我们的研究结果表明,益生菌可以防止口腔病原体的生长并改善口腔健康,从而深入了解不同益生菌种类的抗病原体功效及其在改善口腔健康的功能性食品中的潜在作用。
更新日期:2020-02-11
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