Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration.,Macromolecular Bioscience

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Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-02-11 , DOI: 10.1002/mabi.201900342
Essi Taipaleenmäki ₁ , Brigitte Städler ₁

Affiliation

Oral administration of actives is the most desired form of delivery, but the formulations need to overcome a variety of barriers including the intestinal mucus. This feature article summarizes the developments from the past 2–3 years in this context focusing on polymer‐based formulations. The progress in assembling mucopenetrating nanoparticles is outlined considering coatings using noninteracting polymers as well as virus‐like particles and charge‐shifting particles. Next, polymers and their modification to enhance mucoadhesion are discussed, followed by providing examples of double‐encapsulation systems that aim to combine mucopenetration with mucoadhesion in the same formulation. Finally, a short outlook is provided highlighting a few of the most pressing challenges to address.

中文翻译：

使用聚合物进行肠粘膜粘连和粘膜渗透的最新进展。

口服活性物质是最理想的递送形式，但是该制剂需要克服各种障碍，包括肠粘液。这篇专题文章总结了过去2-3年在此背景下的发展，重点是基于聚合物的配方。考虑到使用非相互作用聚合物以及病毒样颗粒和电荷转移颗粒的涂层，概述了粘膜渗透性纳米颗粒的组装进展。接下来，将讨论聚合物及其对增强粘膜粘附性的修饰，然后提供旨在将粘膜渗透性与粘膜粘附性结合在同一配方中的双包封系统示例。最后，我们提供了一个简短的展望，突出了一些最紧迫的挑战。

更新日期：2020-02-11

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