Cecal ligation and puncture (CLP) is a commonly used model of sepsis in vivo. We investigated the effects of dexpanthenol (DXP) on heart, lung and aorta in CLP-induced sepsis in rats. Rats were divided into four groups of eight: group 1, sham (SH); group 2 (DXP), 500 mg/kg DXP injected intraperitoneally (i.p.); group 3 (CLP), CLP performed; group 4 (CLP + DXP), 500 mg/kg DXP injected i.p. after CLP. Heart, lung and aorta specimens were harvested for histopathological and biochemical analysis. Heart rate increased in group 3 compared to group 1; DXP administration to group 4 did not alleviate this change. In heart tissue samples, MDA levels were decreased significantly in groups 2 and 4 compared to group 3. The levels of GSH in groups 2 and 3 were elevated compared to groups 1 and 2. SOD activity was increased significantly in group 4 compared to group 3. CAT activity for group 4 was increased significantly compared to groups 1 and 3. We found that caspase-9 and caspase-3 activity was increased after application of CLP. Also, DXP treatment decreased the number of caspase-positive cells significantly compared to group 3. DXP appears to be promising for reducing sepsis-related mortality.

盲肠结扎穿刺（CLP）是体内败血症的常用模型。我们调查了地芬太酚（DXP）对CLP诱导的脓毒症大鼠心，肺和主动脉的影响。将大鼠分成四组，每组八组：第1组，假（SH）；第2组，第3组。第2组（DXP），腹膜内注射（ip）500 mg / kg DXP；第3组（CLP），执行CLP；第4组（CLP + DXP），CLP后经腹腔注射500 mg / kg DXP。采集心脏，肺和主动脉标本进行组织病理学和生化分析。与第1组相比，第3组的心率增加；DXP管理到第4组并没有缓解此更改。在心脏组织样品中，与第3组相比，第2和第4组的MDA水平明显降低。与第1和第2组相比，第2和第3组的GSH水平升高。与第3组相比，第4组的SOD活性显着增加。与第1组和第3组相比，第4组的CAT活性显着增加。我们发现应用CLP后caspase-9和caspase-3活性增加。而且，与第3组相比，DXP治疗显着降低了caspase阳性细胞的数量。DXP似乎有望降低败血症相关的死亡率。