BACKGROUND Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk. PURPOSE To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference). METHODS Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics. RESULTS Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (β = .011, p = .047) but not PAI-1 (p = .285). Percentage body fat and waist circumference were positively related to depression symptoms (p = .026 and p = .028, respectively) and log hs-CRP (p < .001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI: .0006, .0119) and waist circumference (95% CI: .0004, .0109) were statistically significant. CONCLUSIONS Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years.

中文翻译：

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西班牙裔/拉丁裔青年的肥胖、抑郁症状和炎症：HCHS/SOL 青年的结果。

背景炎症被认为是与慢性疾病发展相关的许多因素之一；因此，确定其可改变的风险因素为降低风险提供了潜在的干预目标。目的 调查抑郁和焦虑症状是否可能通过睡眠时间和肥胖（即体脂百分比和腰围）间接影响高敏 C 反应蛋白 (hs-CRP) 和纤溶酶原激活剂抑制剂-1 (PAI-1)。方法 对拉丁裔青年（8-16 岁）的西班牙裔社区健康研究/研究横断面基线数据进行多元回归分析，对抽样设计进行加权调整。在临床评估中收集数据，包括空腹血样、自我报告调查和客观测量的人体测量学。结果 调整社会人口统计学协变量后，抑郁症状与 log hs-CRP (β = .011, p = .047) 相关，但与 PAI-1 (p = .285) 无关。体脂百分比和腰围与抑郁症状（分别为 p = .026 和 p = .028）和 log hs-CRP（两者 p < .001）呈正相关。当将肥胖纳入 hs-CRP 模型时，抑郁症状与 hs-CRP 的关联减弱并变得不显着。蒙特卡罗置信区间 (CI) 显示，通过体脂百分比 (95% CI: .0006, .0119) 和腰围 (95% CI: .0004, .0109) 从抑郁症状对 CRP 的间接影响具有统计学意义。结论 结果表明，心理困扰和炎症之间的关联可能通过西班牙裔/拉丁裔儿童的肥胖间接发生。如果研究结果在因果设计中得到复制，那么减少西班牙裔/拉丁裔儿童的抑郁症状和肥胖可能是以后炎症一级预防的途径。