BACKGROUND Cochlear implants (CIs) have become important for the treatment of severe-to-profound sensorineural hearing loss (SNHL). Meanwhile, electrically evoked compound action potentials (ECAPs) and electrically evoked auditory brainstem responses (EABRs), which can be examined and evaluated with minimal patient cooperation, have become more reliable for tone measurement and speech recognition postoperatively. However, few studies have compared the electrophysiological characteristics of the auditory nerve using ECAPs and EABRs under different functional states of the auditory nerve (FSANs). We used guinea pig models in which six electrodes were implanted unilaterally with continuous electrical stimulation (ES) for 4 h. The amplitude growth functions (AGFs) of the alternating polarity ECAP (AP-ECAP) and forward-masking subtraction ECAP (FM-ECAP), as well as the EABR waves under "normal" and "abnormal" FSANs, were obtained. RESULTS Both the AP-ECAP and FM-ECAP thresholds were significantly higher than those measured by EABR under both "normal" FSAN and "abnormal" FSANs (p < 0.05). There was a significant difference in the slope values between electrodes 1 and 2 and electrodes 3 and 4 in terms of the AP-ECAP under the "abnormal" FSAN (p < 0.05). The threshold gaps between the AP-ECAP and FM-ECAP were significantly larger under the "abnormal" FSAN than under the "normal" FSAN (p < 0.05). CONCLUSIONS Both of the ECAP thresholds were higher than the EABR thresholds. The AP-ECAP was more sensitive than the FM-ECAP under the "abnormal" FSAN.

中文翻译：

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不同方法检测听觉神经功能异常的敏感性。

背景技术耳蜗植入物（CI）对于治疗严重至深层的感音神经性听力损失（SNHL）已变得重要。同时，可以在最少的患者配合下进行检查和评估的电诱发复合动作电位（ECAP）和电诱发听觉脑干反应（EABR）对于术后的语气测量和语音识别变得更加可靠。但是，很少有研究在不同的听神经功能状态（FSAN）下使用ECAP和EABR比较听神经的电生理特性。我们使用豚鼠模型，其中六个电极单侧植入连续电刺激（ES）4小时。获得了交替极性ECAP（AP-ECAP）和前向屏蔽减法ECAP（FM-ECAP）的振幅增长函数（AGFs），以及在“正常”和“异常” FSAN下的EABR波。结果AP-ECAP和FM-ECAP阈值均显着高于EABR在“正常” FSAN和“异常” FSAN下测得的阈值（p <0.05）。根据“异常” FSAN下的AP-ECAP，电极1和2与电极3和4之间的斜率值存在显着差异（p <0.05）。在“异常” FSAN下，AP-ECAP和FM-ECAP之间的阈值差距明显大于在“正常” FSAN下的阈值差距（p <0.05）。结论两个ECAP阈值均高于EABR阈值。