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Polygenic score for neuroticism is related to sleep difficulties.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-02-11 , DOI: 10.1111/gbb.12644 Yannick Stephan 1 , Angelina R Sutin 2 , Martina Luchetti 2 , Antonio Terracciano 2
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-02-11 , DOI: 10.1111/gbb.12644 Yannick Stephan 1 , Angelina R Sutin 2 , Martina Luchetti 2 , Antonio Terracciano 2
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Neuroticism, a broad trait measure of the tendency to experience negative emotions and vulnerability to stress, is consistently related to poor sleep quality. Less is known about potential pleiotropy in the genetic risk for high neuroticism and poor sleep. Therefore, the present study examined whether polygenic score (PGS) for neuroticism is related to sleep quality in two large samples of adults. In addition, depressive symptoms, anxiety and phenotypical neuroticism were tested as mediators in both samples. Participants were 8316 individuals aged from 50 to 101 years (mean age = 68.29, SD = 9.83) from the Health and Retirement Study, and 4973 individuals aged from 63 to 67 years (mean age = 64.30, SD = 0.68) from the Wisconsin Longitudinal Study. Participants from both samples were genotyped and answered questions on sleep quality. A higher PGS for neuroticism was related to lower sleep quality concurrently and over time in both samples. Anxiety, depressive symptoms and neuroticism mediated these relationships in the two samples. Although effect sizes were small, the present study provides replicable evidence that individuals with a higher genetic predisposition to experience negative emotions and distress are at risk of sleep difficulties.
中文翻译：
神经质的多基因评分与睡眠困难有关。
神经质是对经历负面情绪和承受压力的倾向的广泛性状度量，一直与睡眠质量差有关。关于高度神经质和不良睡眠的遗传风险中潜在的多效性知之甚少。因此，本研究检查了两个成年人样本中神经质的多基因评分（PGS）是否与睡眠质量有关。此外，在两个样本中，抑郁症状，焦虑和表型神经质都作为介质进行了测试。参与者来自健康与退休研究，年龄从50到101岁（平均年龄= 68.29，SD = 9.83）的8316个人，以及从威斯康星州纵向（Wisconsin Longitudinal）到63-67岁（平均年龄= 64.30，SD = 0.68）的4973个人。研究。对两个样本的参与者进行了基因分型，并回答了有关睡眠质量的问题。在两个样本中，较高的神经质PGS与同时并随着时间的推移降低睡眠质量有关。焦虑，抑郁症状和神经质在两个样品中介导了这些关系。尽管影响的大小很小，但本研究提供了可复制的证据，表明具有较高遗传易感性的个人会遭受负面情绪和困扰的可能性有睡眠困难的风险。
更新日期：2020-02-11
中文翻译：
神经质的多基因评分与睡眠困难有关。
神经质是对经历负面情绪和承受压力的倾向的广泛性状度量，一直与睡眠质量差有关。关于高度神经质和不良睡眠的遗传风险中潜在的多效性知之甚少。因此，本研究检查了两个成年人样本中神经质的多基因评分（PGS）是否与睡眠质量有关。此外，在两个样本中，抑郁症状，焦虑和表型神经质都作为介质进行了测试。参与者来自健康与退休研究，年龄从50到101岁（平均年龄= 68.29，SD = 9.83）的8316个人，以及从威斯康星州纵向（Wisconsin Longitudinal）到63-67岁（平均年龄= 64.30，SD = 0.68）的4973个人。研究。对两个样本的参与者进行了基因分型，并回答了有关睡眠质量的问题。在两个样本中，较高的神经质PGS与同时并随着时间的推移降低睡眠质量有关。焦虑，抑郁症状和神经质在两个样品中介导了这些关系。尽管影响的大小很小，但本研究提供了可复制的证据，表明具有较高遗传易感性的个人会遭受负面情绪和困扰的可能性有睡眠困难的风险。
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