Interactions between hormones and epigenetic factors are key regulators of behaviour, but the mechanisms that underlie their effects are complex. Epigenetic factors can modify sensitivity to hormones by altering hormone receptor expression, and hormones can regulate epigenetic factors by recruiting epigenetic regulators to DNA. The bidirectional nature of this relationship is becoming increasingly evident and suggests that the ability of hormones to regulate certain forms of behaviour may depend on their ability to induce changes in the epigenome. Moreover, sex differences have been reported for several epigenetic modifications, and epigenetic factors are thought to regulate sexual differentiation of behaviour, although specific mechanisms remain to be understood. Indeed, hormone-epigenome interactions are highly complex and involve both canonical and non-canonical regulatory pathways that may permit for highly specific gene regulation to promote variable forms of behavioural adaptation.

中文翻译：

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行为调节中的激素表观基因组相互作用。

激素与表观遗传因素之间的相互作用是行为的关键调节因素，但影响其作用的机制却很复杂。表观遗传因子可以通过改变激素受体的表达来改变对激素的敏感性，而激素可以通过向DNA募集表观遗传调节剂来调节表观遗传因子。这种关系的双向性质变得越来越明显，表明激素调节某些行为形式的能力可能取决于它们诱导表观基因组变化的能力。而且，已经报道了几种表观遗传修饰的性别差异，尽管仍需了解具体的机制，但表观遗传因素被认为可调节行为的性别分化。确实，