Lymphoid malignancies typically promote an infiltrate of immune cells at sites involved by the disease. While some of the immune cells present in lymphoma have effector function, the immune system is unable to eradicate the malignant clone. Therapies that optimize immune function therefore have the potential to improve the outcome of lymphoma patients. In this Review, we discuss immunologic approaches that directly target the malignant cell as well as approaches to optimize both the innate and adaptive immune response to the tumor. While many of these therapies have shown single-agent activity, the future will clearly require thoughtful combinations of these approaches.

中文翻译：

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淋巴瘤的免疫治疗。

淋巴恶性肿瘤通常会促进免疫细胞在该疾病涉及的部位浸润。虽然淋巴瘤中存在的某些免疫细胞具有效应子功能，但免疫系统无法根除恶性克隆。因此，优化免疫功能的疗法具有改善淋巴瘤患者预后的潜力。在这篇综述中，我们讨论了直接针对恶性细胞的免疫学方法以及优化对肿瘤的先天性和适应性免疫反应的方法。尽管许多此类疗法已显示出单药活性，但未来显然需要这些方法的周到组合。