Therapeutic peptides (TPs) are biological macromolecules which can act as neurotransmitters, hormones, ion channel ligands and growth factors. Undoubtedly, TPs are crucial in modern medicine. But low bio-stability and some special adverse reactions reduce their places to the application. With the development of nanotechnology, nanoparticles (NPs) in pharmaceutical science gained much attention. They can encapsulate the TPs into their membrane or shell. Therefore, they can protect the TPs against degradation and then increase the bioavailability, which was thought to be the biggest advantage of them. Additionally, targeting was also studied to improve the effect of TPs. However, there were some drawbacks of nano TPs like low loading efficiency and difficulty to manufacture. Nowadays, lots of studies focused on improving effect of TPs by preparing nanoparticles. In this review, we presented a brief analysis of peptide-combined nanoparticles. Their advantages and disadvantages were listed in terms of mechanism. And several examples of applications were summarized.

中文翻译：

---

肽结合纳米颗粒的简要分析：纳米医学的独特价值。

治疗性肽（TPs）是生物大分子，可以充当神经递质，激素，离子通道配体和生长因子。毫无疑问，TP在现代医学中至关重要。但是低的生物稳定性和一些特殊的不良反应减少了它们在应用中的位置。随着纳米技术的发展，制药科学中的纳米颗粒（NPs）得到了极大的关注。他们可以将TP封装到其膜或外壳中。因此，它们可以保护TP免受降解，然后增加生物利用度，这被认为是它们的最大优势。另外，还研究了靶向作用以改善TP的作用。然而，纳米TP存在一些缺点，例如低的装载效率和难以制造。如今，许多研究着重于通过制备纳米颗粒来改善TP的效果。在这篇综述中，我们对肽结合的纳米颗粒进行了简要分析。从机制方面列出了它们的优缺点。并总结了几个应用示例。