OBJECTIVES We aimed to compare the outcomes of exercise rehabilitation and conventional treatment in patients with knee osteoarthritis. METHODS This trial included a total of 166 patients diagnosed with knee osteoarthritis; they were randomly divided into groups. The experimental group underwent systematic exercise rehabilitation, while the control group received naproxen (n = 28), diclofenac (n = 27), or celecoxib (n = 19). Improvement in symptoms, knee function, and quality of life were compared. SPSS Statistics 24.0 was used for the data analysis. RESULTS The mean age of patients was 56.0 ± 10.5 years, and the average follow-up time was 12 ± 2.3 weeks. No statistically significant differences were seen in age, body mass index, and sex (P > 0.05) between the groups. The average Western Ontario and MacMaster Universities (WOMAC) scores after treatment were 84.4 ± 15.2, 108.3 ± 3.9, 107.4 ± 5.4, and 107 ± 6.0 in the exercise rehabilitation, diclofenac, naproxen, and celecoxib groups, respectively. The mean Lysholm scores were 60.3 ± 14.9, 41.0 ± 0.1, 43.5 ± 5.3, and 41.7 ± 3.6 in the exercise rehabilitation, diclofenac, naproxen, and celecoxib groups, respectively. The mean SF-36 (Short Form-36 Survey) scores were 105.4 ± 21.5, 82.5 ± 3.7, 84.2 ± 3.5, and 83.7 ± 5.0 in the exercise rehabilitation, naproxen, celecoxib, and diclofenac groups, respectively. The average ranges of knee motion were 125.0 ± 6.2°, 116.4 ± 1.4°, 114.7 ± 1.1°, and 115.7 ± 0.8° after exercise rehabilitation, diclofenac, naproxen, and celecoxib treatments, respectively. These data presented statistical differences between the groups. CONCLUSION Exercise better improved symptoms and quality of life in patients with knee osteoarthritis over a 12-week follow-up period than that achieved with nonsteroidal anti-inflammatory drugs and COX-2 inhibitors.

中文翻译：

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系统性运动康复对膝关节骨性关节炎患者的影响：一项随机对照试验。

目的 我们旨在比较膝关节骨性关节炎患者运动康复和常规治疗的结果。方法 本试验共纳入 166 名诊断为膝关节骨性关节炎的患者；他们被随机分组​​。实验组接受系统运动康复治疗，对照组接受萘普生（n = 28）、双氯芬酸（n = 27）或塞来昔布（n = 19）。比较症状、膝关节功能和生活质量的改善。SPSS Statistics 24.0用于数据分析。结果患者平均年龄56.0±10.5岁，平均随访时间12±2.3周。组间年龄、体重指数、性别差异无统计学意义（P>0.05）。运动康复组、双氯芬酸组、萘普生组和塞来昔布组治疗后的平均西安大略和麦克马斯特大学 (WOMAC) 评分分别为 84.4 ± 15.2、108.3 ± 3.9、107.4 ± 5.4 和 107 ± 6.0。运动康复组、双氯芬酸组、萘普生组和塞来昔布组的平均 Lysholm 评分分别为 60.3 ± 14.9、41.0 ± 0.1、43.5 ± 5.3 和 41.7 ± 3.6。运动康复、萘普生、塞来昔布和双氯芬酸组的平均 SF-36（Short Form-36 Survey）评分分别为 105.4 ± 21.5、82.5 ± 3.7、84.2 ± 3.5 和 83.7 ± 5.0。运动康复、双氯芬酸、萘普生和塞来昔布治疗后，膝关节活动的平均范围分别为 125.0 ± 6.2°、116.4 ± 1.4°、114.7 ± 1.1° 和 115.7 ± 0.8°。这些数据显示了组间的统计差异。