Fatty acid amide hydrolase (FAAH) degrades the endogenous endocannabinoid (eCB) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores (highs). Since the A allele of the FAAH C385A polymorphism (rs324420) is associated with lower FAAH activity, it was studied in 21 highs, 66 low hypnotizable individuals (lows), and 172 individuals not selected for hypnotizability (controls) representing the general population. No significant difference was observed among groups, but the A allele frequency showed a significant trend to increase from lows to controls and from controls to highs. Since eCB small differences can be amplified by eCB interactions with other neurotransmitters, a contribution of the FAAH polymorphism to the highs' analgesia should not be excluded.

中文翻译：

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与催眠作用有关的FAAH C385A多形性：可能是内源性大麻素，对因糖诱发的镇痛作用做出了贡献。

脂肪酸酰胺水解酶（FAAH）降解内源性内源性大麻素（eCB）anandamide，并可能在催眠力得分高（高）的受试者中对镇痛建议产生反应。由于FAAH C385A多态性的A等位基因（rs324420）与较低的FAAH活性相关，因此在21个高位，66个低催眠状态的个体（低位）和172个未因催眠作用而选择的个体（对照）中进行了研究，代表了普通人群。在各组之间未观察到显着差异，但是A等位基因频率显示出从低端到对照组以及从对照组到高端的显着趋势。由于eCB与其他神经递质的相互作用可放大eCB的微小差异，因此不应排除FAAH多态性对上肢镇痛的作用。