BACKGROUND Seizures are a common presenting sign in dogs with brain tumors. HYPOTHESIS/OBJECTIVES To investigate the effect of radiotherapy on freedom from brain tumor-associated seizures and survival time in dogs. ANIMALS Thirty-two client-owned dogs with brain tumor-associated seizures; 18 received medical treatment and radiotherapy, 14 received medical treatment alone. METHODS Multicenter retrospective study. Baseline characteristics (seizure semiology, magnetic resonance imaging [MRI] characteristics, and treatment) and duration of seizure freedom were recorded for the 2 treatment groups. Duration of seizure freedom between groups was compared (log-rank test) using Cox's proportional hazard analysis, with baseline characteristics entered as covariates. RESULTS The duration of seizure freedom and survival time were significantly longer in the radiotherapy group (P < .001), with a mean of 24 months (95% confidence interval [CI], 14.3-33.8) versus 1.7 months in the control group (95% CI, 0.5-2.9) and a mean of 34.6 months (95% CI: 25.2-44.1) versus 6.2 months in the control group (95% CI, 2.6-9.7) respectively. Baseline characteristics were not associated with duration of seizure freedom after the start of treatment. In the radiotherapy group, 5 dogs were euthanized during the study period because of causes other than seizures. In the control group, recurrence of seizures was observed before death in all dogs. CONCLUSIONS AND CLINICAL IMPORTANCE A longer period of seizure freedom and longer survival time was observed in dogs with brain tumors after radiotherapy compared to medical treatment only. The pathophysiological mechanisms of epileptogenesis and the effect of radiation therapy on seizure control are unclear to date. Further prospective studies are needed.

中文翻译：

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放疗对患有脑肿瘤的狗免受癫痫发作的影响。

背景技术癫痫发作是患有脑肿瘤的狗中的常见症状。假设/目的探讨放射治疗对犬免于与脑瘤相关的癫痫发作和存活时间的影响。动物32只与脑瘤相关的癫痫发作的客户拥有的狗；18例接受了医疗和放疗，仅14例接受了医疗。方法多中心回顾性研究。记录了两个治疗组的基线特征（癫痫发作符号学，磁共振成像[MRI]特征和治疗）和癫痫发作的持续时间。使用Cox比例风险分析比较两组之间癫痫发作自由的持续时间（对数秩检验），并将基线特征作为协变量输入。结果放疗组的癫痫发作持续时间和生存时间明显更长（P <.001），平均为24个月（95％置信区间[CI]，14.3-33.8），而对照组为1.7个月（ 95％CI，0.5-2.9）和平均34.6个月（95％CI：25.2-44.1），而对照组分别为6.2个月（95％CI，2.6-9.7）。基线特征与治疗开始后癫痫发作持续时间无关。在放疗组中，由于癫痫发作以外的原因，在研究期间对5只狗实施了安乐死。在对照组中，所有狗在死亡前均观察到癫痫发作的复发。结论和临床意义与仅药物治疗相比，放疗后脑瘤犬的癫痫发作时间更长，生存时间更长。迄今尚不清楚癫痫发生的病理生理机制和放射疗法对癫痫发作控制的作用。需要进一步的前瞻性研究。