Preparation of efficient polyurethane-type wound dressings with tunable physicomechanical properties and widespread antimicrobial activity is considered in this work. A new type of soybean oil-based polyol with built-in urethane and quaternary ammonium groups is synthesized through a nonisocyanate route using carbonated soybean oil as an environmentally friendly, renewable resource-based raw material. Different formulations from this polyol and castor oil are prepared and converted to the polyurethane wound dressings via a reaction with isophorone diisocyanate. The dressing sample, with good cytocompatibility and efficient antimicrobial activity against various microbial strains, having tensile strength of 5 and 17 MPa at hydrated and dry state, elongation at the break of up to 400%, equilibrium water absorption and a water vapor transmission rate of 50% and 390 g m-2 day-1, is used for in vivo assay on a rat. Evaluation of the optimized dressing for a full-thickness non-sterilized wound has shown excellent progress of wound healing, since the tensile strength of regenerated skin reaches about 80% of normal healthy skin on day 21 after wounding. This has been significantly superior to the tensile strength of the regenerated skin of rats covered with non-antibacterial (∼50%) and cotton gauze (∼40%) dressings as blank and control groups.

中文翻译：

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植物油基聚氨酯作为抗菌伤口敷料：体外和体内评估。

在这项工作中考虑制备具有可调物理机械特性和广泛抗菌活性的高效聚氨酯型伤口敷料。以碳酸化豆油为环保、可再生资源型原料，通过非异氰酸酯路线合成了一种新型的内置氨基甲酸酯和季铵基的大豆油基多元醇。用这种多元醇和蓖麻油制备不同的配方，并通过与异佛尔酮二异氰酸酯反应转化为聚氨酯伤口敷料。该敷料样品具有良好的细胞相容性和对各种微生物菌株的高效抗菌活性，在水合和干燥状态下具有5和17 MPa的拉伸强度，断裂伸长率高达400%，平衡吸水率和 50% 的水蒸气透过率和 390 g m-2 day-1，用于大鼠体内试验。对用于全层非消毒伤口的优化敷料的评估显示伤口愈合的良好进展，因为再生皮肤的拉伸强度在伤口后第 21 天达到正常健康皮肤的 80% 左右。这明显优于覆盖非抗菌（~50%）和棉纱布（~40%）敷料作为空白组和对照组的大鼠再生皮肤的拉伸强度。因为在受伤后第 21 天，再生皮肤的拉伸强度达到正常健康皮肤的 80% 左右。这明显优于覆盖非抗菌（~50%）和棉纱布（~40%）敷料作为空白组和对照组的大鼠再生皮肤的拉伸强度。因为在受伤后第 21 天，再生皮肤的拉伸强度达到正常健康皮肤的 80% 左右。这明显优于覆盖非抗菌（~50%）和棉纱布（~40%）敷料作为空白组和对照组的大鼠再生皮肤的拉伸强度。