Purpose of Review

Given the growing challenges in chronic pain management coupled with the ongoing consequences of the opioid epidemic, pain management practitioners are looking into more effective, innovative, and safer alternatives to treat pain. Cannabis-based medicine had been described for hundreds of years but only recently have we seen the more scientific, evidence-based approach to its use, and ongoing investigations continue to explore its potential medical benefits. While historically more attention has been paid to the psychoactive component of the cannabis plant Δ⁹-tetrahydrocannabinol (THC), there have been fewer scientific studies on the medical use of the cannabidiol (CBD) – a non-psychoactive component of the cannabis plant.

Recent Findings

By examining recent literature, we investigated the use of CBD and its potential role in pain management. Since there are currently no approved pharmaceutical products that contain CBD alone for the management of pain, this review focused on nabiximols (which is a combined product of THC/CBD in a 1:1 ratio) as the only pharmaceutical product available that contains CBD and is being used for the management of pain. It is difficult to definitely attribute the therapeutic properties to CBD alone since it is always administered with THC. Based on the available literature, it is difficult to make a recommendation for the use of CBD in chronic pain management. It is also important to note that there are many CBD products currently available as supplements, but these products are non-pharmaceuticals and lack the appropriate clinical studies to support their efficacy claims.

中文翻译：

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卡纳比多二醇（CBD）在慢性疼痛管理中的作用：对当前证据的评估。

审查目的

鉴于慢性疼痛管理中日益严峻的挑战以及阿片类药物流行的持续后果，疼痛管理从业人员正在寻找更有效，创新和更安全的替代方法来治疗疼痛。基于大麻的医学已有数百年的历史了，但是直到最近，我们才看到使用更科学，基于证据的方法，并且正在进行的研究仍在继续探索其潜在的医学益处。虽然以前更加受到人们的重视，以大麻植物Δ的精神成分⁹四氢大麻酚（THC），已经出现了对医疗用大麻的（CBD）的较少的科学研究-大麻植物的非精神的组成部分。

最近的发现

通过查阅最新文献，我们调查了CBD的使用及其在疼痛管理中的潜在作用。由于目前尚无批准的仅含有CBD的药物来治疗疼痛，因此本综述重点关注纳比西莫斯（THC / CBD的比例为1：1的组合产品），因为它是唯一包含CBD和用于治疗疼痛。由于CBD总是与THC一起给药，因此很难将治疗特性仅归因于CBD。根据现有文献，很难就在慢性疼痛治疗中使用CBD提出建议。还需要注意的是，目前有许多CBD产品可作为补充，