Abstract The septins constitute a conserved family of guanosine phosphate-binding and filament-forming proteins widespread across eukaryotic species. Septins appear to have two principal functions. One is to form a cortical diffusion barrier, like the septin collar at the bud neck of Saccharomyces cerevisiae, which prevents movement of membrane-associated proteins between the mother and daughter cells. The second is to serve as a polymeric scaffold for recruiting the proteins required for critical cellular processes to particular subcellular areas. In the last decade, structural information about the different levels of septin organization has appeared, but crucial structural determinants and factors responsible for septin assembly remain largely unknown. This review highlights recent findings on the architecture and function of septins and their remodeling with an emphasis on mitotically dividing budding yeasts.

中文翻译：

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出芽酵母中的 Septin 结构和功能

摘要 septins 是一个保守的磷酸鸟苷结合蛋白和细丝形成蛋白家族，广泛存在于真核生物物种中。Septins 似乎有两个主要功能。一种是形成皮质扩散屏障，如酿酒酵母芽颈处的隔膜环，可防止膜相关蛋白在母细胞和子细胞之间移动。第二个是作为聚合支架，将关键细胞过程所需的蛋白质募集到特定的亚细胞区域。在过去的十年中，关于 septin 组织不同层次的结构信息已经出现，但负责 septin 组装的关键结构决定因素和因素在很大程度上仍然未知。