Limitations associated with immunoglobulins have motivated the search for novel binding scaffolds. Repeat proteins have emerged as one promising class of scaffolds, but often are limited to binding protein and peptide targets. An exception is the repeat proteins of the immune system, which have in recent years served as an inspiration for binding scaffolds which can bind glycans and other classes of biomolecule. Like other repeat proteins, these proteins can be very stable and have a monomeric mode of binding, with elongated and highly variable binding surfaces. The ability to target glycans and glycoproteins fill an important gap in current tools for research and biomedical applications.

中文翻译：

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免疫系统的工程重复蛋白

与免疫球蛋白相关的局限性促使人们寻找新的结合支架。重复蛋白已成为一类有前途的支架，但通常仅限于结合蛋白和肽目标。一个例外是免疫系统的重复蛋白，近年来，它激发了结合支架的灵感，这些支架可以结合聚糖和其他类别的生物分子。与其他重复蛋白质一样，这些蛋白质可以非常稳定，并具有单体结合模式，具有细长且高度可变的结合表面。靶向聚糖和糖蛋白的能力填补了当前研究和生物医学应用工具的重要空白。