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Cross-talk of Signaling Pathways in the Pathogenesis of Allergic Asthma and Cataract.
Protein & Peptide Letters ( IF 1.0 ) Pub Date : 2020-08-31 , DOI: 10.2174/0929866527666200207113439
Yang Zhao 1, 2 , Sumei Liu 3 , Xiangsheng Li 1, 2 , Zhenzhen Xu 1, 2 , Lifang Hao 1, 2 , Zhe Cui 1, 2 , Kewei Bi 1, 2 , Yanfen Zhang 2, 4 , Zhongcheng Liu 1, 2
Affiliation  

Allergic asthma is a chronic inflammatory disease, which involves many cellular and cellular components. Cataract is a condition that affects the transparency of the lens, which the opacity of the lens caused by any innate or acquired factor degrades its transparency or changes in color. Both of them belong to diseases induced by immune disorders or inflammation. We want to confirm the signaling pathways involved in the regulation of asthma and cataract simultaneously, and provide reference for the later related experiments. So we conducted a scoping review of many databases and searched for studies (Academic research published in Wiley, Springer and Bentham from 2000 to 2019) about the possible relationship between asthma and cataract. It was found that during the onset of asthma and cataract, Rho/Rock signaling pathway, Notch signaling pathway, Wnt/β-catenin signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, MAPK signaling pathway, TGF-β1/Smad signaling pathway and NF-κB signaling pathway are all active, so they may have a certain correlation in pathogenesis. Asthma may be associated with cataract through the eight signaling pathways, causing inflammation or immune imbalance based on allergy that can lead to cataract. According to these studies, we speculated that the three most likely signaling pathways are PI3K/AKT, MAPK and NF-κB signaling pathway.



中文翻译:

过敏性哮喘和白内障发病机理中信号通路的串扰。

过敏性哮喘是一种慢性炎症性疾病,涉及许多细胞和细胞成分。白内障是一种影响晶状体透明度的状况,由任何先天或后天因素引起的晶状体不透明度会降低其透明度或颜色变化。它们都属于由免疫失调或炎症引起的疾病。我们希望同时确认哮喘和白内障调节的信号通路,为以后的相关实验提供参考。因此,我们对许多数据库进行了范围界定审查,并搜索了有关哮喘与白内障之间可能关系的研究(2000年至2019年在Wiley,Springer和Bentham上发表的学术研究)。发现在哮喘和白内障发作期间,Rho / Rock信号通路,Notch信号通路,Wnt /β-catenin信号通路,PI3K / AKT信号通路,JAK / STAT信号通路,MAPK信号通路,TGF-β1/ Smad信号通路和NF-κB信号通路均活跃,因此在发病机制中可能存在一定的相关性。哮喘可能通过八种信号传导途径与白内障相关,基于可导致白内障的变态反应引起炎症或免疫失衡。根据这些研究,我们推测三种最可能的信号通路是PI3K / AKT,MAPK和NF-κB信号通路。引起过敏的炎症或免疫失衡,可能导致白内障。根据这些研究,我们推测三种最可能的信号通路是PI3K / AKT,MAPK和NF-κB信号通路。引起过敏的炎症或免疫失衡,可能导致白内障。根据这些研究,我们推测三种最可能的信号通路是PI3K / AKT,MAPK和NF-κB信号通路。

更新日期:2020-10-16
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