Diabetic wound characterizes with a delayed repair as a result of the lack of neoangiogenesis and the excess of inflammation. Natural products such as curcumin have shown great promises in their regulatory potentials on inflammation and angiogenesis. However, natural agents have several shortages in their bioavailability and stability when used in vivo. In this study, we have evaluated the efficacy of a topical formulation of curcumin in the enhancement of diabetic wound repair. Streptozocin‐induced diabetic mice were wounded, and cream of curcumin (1%) was applied topically to wounds twice daily for different treatment periods. Inflammation, neoangiogenesis, and re‐epithelialization were evaluated in each experimental group. Wounds of animals treated with curcumin showed an enhanced neoangiogenesis. Application of topical curcumin also increased the expression level of RelA as the main subunit of the nuclear factor‐κB (NF‐κB ) signalling pathway. However, no significant effects on macrophage polarization and re‐epithelialization were observed in the curcumin‐treated animals. Our study using a higher concentration of curcumin in the form of a topical cream further confirmed the efficacy of curcumin as an angiogenesis‐promoting agent; however, it also conveyed uncertainty over the claimed regulatory effects of curcumin on inflammation.

中文翻译：

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姜黄素的局部应用可调节糖尿病受损皮肤伤口中的血管生成。

由于缺乏新血管生成和炎症过多，糖尿病伤口的特征是修复延迟。天然产品（如姜黄素）在炎症和血管生成方面的调节潜力已显示出广阔的前景。然而，当在体内使用时，天然剂在生物利用度和稳定性方面存在一些不足。在这项研究中，我们评估了姜黄素的局部制剂在增强糖尿病伤口修复中的功效。链脲佐菌素诱导的糖尿病小鼠受伤，姜黄素霜（1％）每天两次在不同的治疗时期局部应用到伤口上。在每个实验组中评估炎症，新血管生成和上皮再形成。用姜黄素治疗的动物的伤口显示出增强的新血管生成。局部姜黄素的应用还增加了RelA的表达水平，它是核因子κB（NF-κB）的主要亚基）信号通路。但是，在用姜黄素治疗的动物中未观察到对巨噬细胞极化和上皮再形成的显着影响。我们的研究以局部乳膏形式使用更高浓度的姜黄素，进一步证实了姜黄素作为促血管生成剂的功效。然而，它也为姜黄素对炎症的调节作用带来了不确定性。