Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD1 is also involved in the apoptotic signaling pathway and mutates in many cancer cells. In the study, we revealed that NOD1 expression decreased during the progression of cervical intraepithelial neoplasia to cervical cancer and that HPV16 E6/E7 oncoproteins induced down-regulation of NOD1. Moreover, the activation of NOD1 promoted the apoptosis of HPV16-positive cervical cancer cells. The data indicated that the dysregulation of NOD1-mediated inflammation and apoptosis may contribute to cervical intraepithelial neoplasia progression and cervical cancer.

中文翻译：

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HPV介导的NOD1下调抑制宫颈癌细胞凋亡

宫颈癌是全球女性第四大常见恶性肿瘤。高危型人乳头瘤病毒 (hrHPV) 的持续感染被认为是该病的主要原因。作为先天免疫受体，核苷酸结合寡聚化域蛋白 1 (NOD1) 识别病原体相关分子模式 (PAMP)，随后启动免疫反应。NOD1 也参与凋亡信号通路并在许多癌细胞中发生突变。在该研究中，我们发现在宫颈上皮内瘤变向宫颈癌进展过程中 NOD1 表达降低，并且 HPV16 E6/E7 癌蛋白诱导 NOD1 下调。此外，NOD1的激活促进了HPV16阳性宫颈癌细胞的凋亡。