Balanced de novo non-robertsonian translocations (non-RTs), which involve acrocentric chromosomes, are rare findings in clinical cytogenetics and may be associated with an abnormal phenotype. These translocations, detected by conventional karyotyping, are found in approximately 1:1,000 neonates. In most of these cases, one of the parents carries the same translocation. In this study, we report a rare non-RT involving chromosomes 15 and 22 defined as 45, XX, -22,der(15;22)t(15;22)/46, XX, der(15)t(15;22),der(22). To our knowledge, this is the first report of a non-RT t(15;22) with these breakpoints.

中文翻译：

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罕见的单卵双胞胎中涉及染色体15和22与先天性异常的马赛克非平衡非罗伯逊易位。

平衡的从头到尾非罗伯逊式易位（non-RTs），涉及到acrocentric染色体，是临床细胞遗传学中罕见的发现，并且可能与异常表型有关。通过常规核型分析检测到的这些易位，大约存在于1：1,000的新生儿中。在大多数情况下，其中一位父母携带相同的易位。在这项研究中，我们报告了一种罕见的非RT，涉及染色体15和22，它们定义为45，XX，-22，der（15; 22）t（15; 22）/ 46，XX，der（15）t（15; 22），der（22）。据我们所知，这是具有这些断点的非RT t（15; 22）的首次报告。