Background and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model.
Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated.
Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P< 0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P< 0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P< 0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P< 0.05).
Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.

Keywords: antioxidant activity, inflammation, mice model, nano-phytosome


中文翻译：

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姜黄素及其纳米植物体对小鼠模型中卡拉胶诱导的炎症的保护作用：行为和生化反应。

背景与目的：天然化合物用于预防炎症。姜黄素具有抗氧化和抗炎特性，将其加载到纳米植物体中可以提高其效率。本研究调查了姜黄素及其纳米植物体对角叉菜胶诱导的小鼠模型炎症的行为和生化反应的影响。
方法：将小鼠分为6组，在给予角叉菜胶前7天口服姜黄素或其纳米植物体，剂量为15 mg/kg。通过向左爪的足底下区域施用角叉菜胶（1%）来诱导小鼠的急性炎症。然后评估抗氧化活性和行为反应。
结果：结果显示，sal+sal组血清抗氧化酶浓度明显高于cara+sal组（P < 0.05）。与 cara+sal 组相比，单独使用或与吲哚美辛联合使用纳米植物体可提高抗氧化酶水平（P < 0.05）。cara+sal 组的潜伏期明显低于 cara+sal 组（P < 0.05），但其他组明显升高，尤其是 cara+nano.ph.cur+indo 组（P < 0.05） .
结论：可以说姜黄素的纳米植物体可以改善炎症小鼠的抗氧化和行为反应。

关键词：抗氧化活性, 炎症, 小鼠模型, 纳米植物体