Abstract.

Zwitterions are a class of unique molecules that can be modified onto nanomaterials to render them with antifouling properties. Here we report a thorough NMR investigation of dendrimers modified with zwitterions in terms of their structure, hydrodynamic size, and diffusion time in aqueous solution. In this present work, poly(amidoamine) (PAMAM) dendrimers of generation 5 (G5) were partially decorated with carboxybetaine acrylamide (CBAA), 2-methacryloyloxyethyl phosphorylcholine (MPC), and 1,3-propane sultone (1,3-PS), respectively with different modification degrees. The formed zwitterion-modified G5 dendrimers were characterized using NMR techniques. We show that the zwitterion modification leads to increased G5 dendrimer size in aqueous solution, suggesting that the modified zwitterions can form a hydration layer on the surface of G5 dendrimers. In addition, the hydrodynamic sizes of G5 dendrimers modified with different zwitterions but with the same degree of surface modification are discrepant depending on the type of zwitterions. The present study provides a new physical insight into the structure of zwitterion-modified G5 dendrimers by NMR techniques, which is beneficial for further design of different biomedical applications.

Graphical abstract

中文翻译：

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通过彻底的NMR研究表征两性离子改性的聚（酰胺基胺）树状聚合物在水溶液中的性质。

摘要。

两性离子是一类独特的分子，可以修饰到纳米材料上，使其具有防污性能。在这里，我们报道了用两性离子修饰的树枝状聚合物在结构，流体动力学尺寸和在水溶液中扩散时间方面的彻底NMR研究。在本工作中，用羧基甜菜碱丙烯酰胺（CBAA），2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）和1,3-丙烷磺酸内酯（1,3-PS ），分别具有不同的修饰度。使用NMR技术表征形成的两性离子修饰的G5树枝状聚合物。我们显示两性离子修饰导致水溶液中G5树状聚合物的尺寸增加，表明修饰的两性离子可在G5树状聚合物的表面形成水合层。此外，取决于两性离子的类型，用不同的两性离子改性但具有相同表面改性程度的G5树枝状聚合物的流体力学尺寸是不同的。本研究通过NMR技术提供了对两性离子修饰的G5树枝状大分子结构的新物理见解，这对进一步设计不同的生物医学应用很有帮助。

图形概要