Atherosclerosis is a major contributor to many cardiovascular events, including myocardial infarction, ischemic stroke, and peripheral arterial disease, making it the leading cause of death worldwide. High-density lipoproteins (HDL), also known as “good cholesterol”, have been shown to demonstrate anti-atherosclerotic efficacy through the removal of cholesterol from foam cells in atherosclerotic plaques. Because of the excellent anti-atherosclerotic properties of HDL, in the past several years, there has been tremendous attention in designing HDL mimicking nanoparticles (NPs) of varying functions to image, target, and treat atherosclerosis. In this review, we are summarizing the recent progress in the development of HDL mimicking NPs and their applications for atherosclerosis.

中文翻译：

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用于动脉粥样硬化的高密度脂蛋白模拟纳米粒子。

动脉粥样硬化是许多心血管事件的主要原因，包括心肌梗塞、缺血性中风和外周动脉疾病，使其成为全球死亡的主要原因。高密度脂蛋白（HDL），也被称为“好胆固醇”，已被证明可以通过清除动脉粥样硬化斑块中泡沫细胞中的胆固醇而发挥抗动脉粥样硬化功效。由于HDL具有优异的抗动脉粥样硬化特性，在过去的几年中，设计不同功能的HDL模拟纳米粒子（NP）以成像、靶向和治疗动脉粥样硬化受到了极大的关注。在这篇综述中，我们总结了模拟 HDL 纳米粒子的开发及其在动脉粥样硬化中的应用的最新进展。