Medulloblastoma (MB) is a malignant intracranial tumor. Cisplatin is a broad‐spectrum antitumor drug. It is important to study the cisplatin resistance of MB cells for the treatment of MB. In this article, we preliminarily studied the cisplatin resistance of microRNA (miR)‐31 and the possible mechanism in DAOY and UW228 cells, laying a theoretical foundation for clinical treatment of MB.

中文翻译：

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MicroRNA-31 通过 NF-κB 和 PI3K/AKT 通路减弱髓母细胞瘤细胞的顺铂耐药性。

髓母细胞瘤（MB）是一种恶性颅内肿瘤。顺铂是一种广谱抗肿瘤药物。研究MB细胞的顺铂耐药性对于MB的治疗具有重要意义。本文初步研究了microRNA (miR)-31对顺铂的耐药性及其在DAOY和UW228细胞中的可能机制，为临床治疗MB奠定了理论基础。