当前位置：
X-MOL 学术
›
J. Neurosci. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Neurocognitive and psychiatric disorders-related axonal degeneration in Parkinson's disease.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-02-05 , DOI: 10.1002/jnr.24584 Christina Andica 1 , Koji Kamagata 1 , Taku Hatano 2 , Yuya Saito 1, 3 , Wataru Uchida 1, 3 , Takashi Ogawa 2 , Haruka Takeshige-Amano 2 , Akifumi Hagiwara 1 , Syo Murata 1 , Genko Oyama 2 , Yashushi Shimo 2 , Atsushi Umemura 4 , Toshiaki Akashi 1 , Akihiko Wada 1 , Kanako K Kumamaru 1 , Masaaki Hori 1, 5 , Nobutaka Hattori 2 , Shigeki Aoki 1
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-02-05 , DOI: 10.1002/jnr.24584 Christina Andica 1 , Koji Kamagata 1 , Taku Hatano 2 , Yuya Saito 1, 3 , Wataru Uchida 1, 3 , Takashi Ogawa 2 , Haruka Takeshige-Amano 2 , Akifumi Hagiwara 1 , Syo Murata 1 , Genko Oyama 2 , Yashushi Shimo 2 , Atsushi Umemura 4 , Toshiaki Akashi 1 , Akihiko Wada 1 , Kanako K Kumamaru 1 , Masaaki Hori 1, 5 , Nobutaka Hattori 2 , Shigeki Aoki 1
Affiliation
|
Neurocognitive and psychiatric disorders have significant consequences for quality of life in patients with Parkinson's disease (PD). In the current study, we evaluated microstructural white matter (WM) alterations associated with neurocognitive and psychiatric disorders in PD using neurite orientation dispersion and density imaging (NODDI) and linked independent component analysis (LICA). The indices of NODDI were compared between 20 and 19 patients with PD with and without neurocognitive and psychiatric disorders, respectively, and 25 healthy controls using tract-based spatial statistics and tract-of-interest analyses. LICA was applied to model inter-subject variability across measures. A widespread reduction in axonal density (indexed by intracellular volume fraction [ICVF]) was demonstrated in PD patients with and without neurocognitive and psychiatric disorders, as compared with healthy controls. Compared with patients without neurocognitive and psychiatric disorders, patients with neurocognitive and psychiatric disorders exhibited more extensive (posterior predominant) decreases in axonal density. Using LICA, ICVF demonstrated the highest contribution (59% weight) to the main effects of diagnosis that reflected widespread decreases in axonal density. These findings suggest that axonal loss is a major factor underlying WM pathology related to neurocognitive and psychiatric disorders in PD, whereas patients with neurocognitive and psychiatric disorders had broader axonal pathology, as compared with those without. LICA suggested that the ICVF can be used as a useful biomarker of microstructural changes in the WM related to neurocognitive and psychiatric disorders in PD.
中文翻译：
与帕金森氏病有关的神经认知和精神疾病相关的轴突变性。
神经认知障碍和精神疾病会对帕金森氏病（PD）患者的生活质量产生重大影响。在当前的研究中，我们使用神经突取向分散和密度成像（NODDI）和关联独立成分分析（LICA）评估了PD中与神经认知和精神疾病相关的微结构白质（WM）改变。使用基于空间的空间统计和相关分析，分别比较了20例和19例有无神经认知和精神疾病的PD患者和25例健康对照者的NODDI指数。LICA被用于模拟跨度量的受试者间变异性。与健康对照相比，在有和没有神经认知和精神疾病的PD患者中，轴突密度普遍降低（以细胞内体积分数[ICVF]指数）。与没有神经认知和精神病患者的患者相比，患有神经认知和精神病患者的患者轴突密度降低的幅度更大（以后为主）。使用LICA，ICVF对诊断的主要作用表现出最高的贡献（59％的重量），这反映了轴突密度的普遍下降。这些发现表明，轴突丢失是PD中与神经认知和精神疾病有关的WM病理的主要因素，而与没有认知障碍和精神疾病的患者相比，患有神经认知和精神疾病的患者的轴索病理更为广泛。
更新日期：2020-02-05
中文翻译：
与帕金森氏病有关的神经认知和精神疾病相关的轴突变性。
神经认知障碍和精神疾病会对帕金森氏病（PD）患者的生活质量产生重大影响。在当前的研究中，我们使用神经突取向分散和密度成像（NODDI）和关联独立成分分析（LICA）评估了PD中与神经认知和精神疾病相关的微结构白质（WM）改变。使用基于空间的空间统计和相关分析，分别比较了20例和19例有无神经认知和精神疾病的PD患者和25例健康对照者的NODDI指数。LICA被用于模拟跨度量的受试者间变异性。与健康对照相比，在有和没有神经认知和精神疾病的PD患者中，轴突密度普遍降低（以细胞内体积分数[ICVF]指数）。与没有神经认知和精神病患者的患者相比，患有神经认知和精神病患者的患者轴突密度降低的幅度更大（以后为主）。使用LICA，ICVF对诊断的主要作用表现出最高的贡献（59％的重量），这反映了轴突密度的普遍下降。这些发现表明，轴突丢失是PD中与神经认知和精神疾病有关的WM病理的主要因素，而与没有认知障碍和精神疾病的患者相比，患有神经认知和精神疾病的患者的轴索病理更为广泛。
京公网安备 11010802027423号