Abstract

Two new benzoic acid derivatives (1–2), together with four known compounds (3–6) have been isolated from the n-BuOH soluble fraction of ethanolic extract from Ailanthus altissima. The gross structures of the new compounds were deduced by detailed spectroscopic analysis including HRESIMS and 1D/2D NMR spectroscopy. The stereochemistry of 1 was determined by modified Mosher’s method. All compounds were evaluated for their neuroprotective effects against H₂O₂-induced oxidative stress in human neuroblastoma SH-SY5Y cells and none of them displayed obvious neuroprotective activities.

中文翻译：

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臭椿根皮中的苯甲酸衍生物

摘要

两个新的苯甲酸衍生物（1 - 2），加上四个已知化合物（3 - 6）已经从分离Ñ从乙醇提取物的-BuOH可溶组分臭椿。通过详细的光谱分析（包括HRESIMS和1D / 2D NMR光谱）推论出新化合物的总体结构。1的立体化学通过改良的Mosher方法测定。评估了所有化合物对人神经母细胞瘤SH-SY5Y细胞中H ₂ O ₂诱导的氧化应激的神经保护作用，没有一个具有明显的神经保护活性。