In mammals, adaptive immunity is mediated by a broadly diverse repertoire of naive B and T lymphocytes that recirculate between secondary lymphoid organs. Initial antigen exposure promotes lymphocyte clonal expansion and differentiation, including the formation of memory cells. Antigen-specific memory cells are maintained at higher frequencies than their naive counterparts and have different functional and homing abilities. Importantly, a subset of memory cells, known as tissue-resident memory cells, is maintained without recirculating in nonlymphoid tissues, often at barrier surfaces, where they can be reactivated by antigen and rapidly perform effector functions that help protect the tissue in which they reside. Although antigen-experienced B cells are abundant at many barrier surfaces, their characterization as tissue-resident memory B (BRM) cells is not well developed. In this study, we describe the characteristics of memory B cells in various locations and discuss their possible contributions to immunity and homeostasis as bona fide BRM cells.

中文翻译：

---

驻留记忆 B 细胞。

在哺乳动物中，适应性免疫是由在次级淋巴器官之间再循环的多种原始 B 和 T 淋巴细胞介导的。初始抗原暴露促进淋巴细胞克隆扩增和分化，包括记忆细胞的形成。抗原特异性记忆细胞比其原始对应物保持更高的频率，并且具有不同的功能和归巢能力。重要的是，记忆细胞的一个子集，称为组织驻留记忆细胞，在非淋巴组织中保持不再循环，通常在屏障表面，在那里它们可以被抗原重新激活并快速执行效应功能，帮助保护它们所在的组织。尽管经历过抗原的 B 细胞在许多屏障表面大量存在，但它们作为组织驻留记忆 B (BRM) 细胞的特性尚未得到充分发展。在这项研究中，我们描述了不同位置的记忆 B 细胞的特征，并讨论了它们作为真正的BRM 细胞对免疫和稳态的可能贡献。