PURPOSE To compare 1 year post-embolization reperfusion rates in pulmonary arteriovenous malformations (PAVMs) treated with the 0.035″ Interlock™ Fibered IDC™ Occlusion System coils (IDC) (Boston Scientific, Marlborough, Massachusetts) versus 0.035″ Nester coils (Cook Medical Inc., Bloomington, Indiana). MATERIALS AND METHODS A randomized controlled trial was performed randomizing individual PAVMs to treatment with IDC versus Nester coils at the largest hereditary hemorrhagic telangiectasia center in Canada. The primary outcome was CT evidence of reperfusion at 1 year. Secondary outcomes included periprocedural complications, fluoroscopy time and contrast volume. RESULTS Our study was terminated prematurely due to slow recruitment and subsequent expiration of funding. A total of 46 PAVMs in 25 patients (64% female) were included in our study; 26 randomized to Nester coils and 20 randomized to IDC. One patient was lost to follow-up. At a mean follow-up of 421.2 ± 215.7 days, no significant difference in PAVM reperfusion was detected between Nester coils and IDC (0% vs. 5.6%, p > 0.05). No major periprocedural complications were noted in either group. Fluoroscopy time (Nester: 15.0 ± 11.8 min vs. IDC 16.0 ± 5.4 min, p > 0.05) and contrast volume (Nester: 80.3 ± 36.5 ml vs. IDC 87.3 ± 51.7 ml, p > 0.05) utilized did not differ between groups. CONCLUSION No significant difference was detected in PAVM reperfusion rates, periprocedural complication rates, contrast volume utilization or fluoroscopy time following embolization with IDC and Nester coils.

中文翻译：

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栓塞治疗后肺动静脉畸形的再灌注：可分离与可推进线圈的随机对照试验。

目的比较用0.035“ Interlock™纤维IDC™阻塞系统线圈（IDC）（波士顿科学，马萨诸塞州波士顿市）与0.035” Nester线圈（Cook Medical Inc.）治疗的肺动静脉畸形（PAVM）栓塞后1年再灌注率。，Bloomington，Indiana）。材料与方法在加拿大最大的遗传性出血性毛细血管扩张中心，对单个PAVM进行IDC与Nester线圈治疗的随机对照试验。主要结果是1年时再灌注的CT证据。次要结局包括围手术期并发症，透视检查时间和造影剂体积。结果由于招聘缓慢和随后的资金到期，我们的研究提前终止。本研究共纳入25例患者（46％为女性）中的46例PAVM。将26个随机分配给Nester线圈，将20个随机分配给IDC。一名患者失访。平均随访时间为421.2±215.7天，在Nester线圈和IDC之间未检测到PAVM再灌注的显着差异（0％对5.6％，p> 0.05）。两组均未发现严重的围手术期并发症。两组的透视时间（Nester：15.0±11.8分钟，IDC 16.0±5.4分钟，p> 0.05）和造影剂体积（Nester：80.3±36.5 ml vs. IDC 87.3±51.7 ml，p> 0.05）在两组之间没有差异。结论在IDC和Nester线圈栓塞后，PAVM的再灌注率，围手术期并发症发生率，造影剂利用率或透视时间均无显着差异。在Nester线圈和IDC之间未检测到PAVM再灌注的显着差异（0％对5.6％，p> 0.05）。两组均未发现严重的围手术期并发症。两组的透视时间（Nester：15.0±11.8分钟，IDC 16.0±5.4分钟，p> 0.05）和造影剂体积（Nester：80.3±36.5 ml vs. IDC 87.3±51.7 ml，p> 0.05）在两组之间没有差异。结论在IDC和Nester线圈栓塞后，PAVM再灌注率，围手术期并发症发生率，造影剂利用率或荧光检查时间均无显着差异。在Nester线圈和IDC之间未检测到PAVM再灌注的显着差异（0％对5.6％，p> 0.05）。两组均未发现严重的围手术期并发症。两组的透视时间（Nester：15.0±11.8分钟，IDC 16.0±5.4分钟，p> 0.05）和造影剂体积（Nester：80.3±36.5 ml vs. IDC 87.3±51.7 ml，p> 0.05）在两组之间没有差异。结论在IDC和Nester线圈栓塞后，PAVM的再灌注率，围手术期并发症发生率，造影剂利用率或透视时间均无显着差异。05）和使用的对比剂体积（Nester：80.3±36.5 ml与IDC 87.3±51.7 ml，p> 0.05）在两组之间没有差异。结论在IDC和Nester线圈栓塞后，PAVM再灌注率，围手术期并发症发生率，造影剂利用率或荧光检查时间均无显着差异。05）和对比体积（Nester：80.3±36.5 ml与IDC 87.3±51.7 ml，p> 0.05）在两组之间没有差异。结论在IDC和Nester线圈栓塞后，PAVM的再灌注率，围手术期并发症发生率，造影剂利用率或透视时间均无显着差异。